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    RabX4 RabX4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42960, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RabX4provided by FlyBase
    Official Full Name
    RabX4provided by FlyBase
    Primary source
    FLYBASE:FBgn0051118
    Locus tag
    Dmel_CG31118
    See related
    AllianceGenome:FB:FBgn0051118
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF56345; CG13638; CG31118; Dmel\CG31118; DmRabX4; rabX4
    Summary
    Predicted to enable GTPase activity. Predicted to be involved in several processes, including Rab protein signal transduction; cellular response to insulin stimulus; and secretion by cell. Located in neuronal cell body and synapse. Is expressed in adult head; imaginal disc; nervous system; and photoreceptor. Orthologous to human RAB12 (RAB12, member RAS oncogene family); RAB13 (RAB13, member RAS oncogene family); and RAB15 (RAB15, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See RabX4 in Genome Data Viewer
    Location:
    96A24-96A24; 3-85 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24826665..24828409, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20652387..20654131, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene nimA-like kinase Neighboring gene long non-coding RNA:CR43166 Neighboring gene Katazuke Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45216 Neighboring gene sosie

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A toolkit for converting Gal4 into LexA and Flippase transgenes in Drosophila. Karuparti S, et al. G3 (Bethesda), 2023 Mar 9. PMID 36617215, Free PMC Article
    2. The Drosophila TRPL ion channel shares a Rab-dependent translocation pathway with rhodopsin. Oberegelsbacher C, et al. Eur J Cell Biol, 2011 Aug. PMID 21507505
    3. Commissureless regulation of axon outgrowth across the midline is independent of Rab function. van den Brink DM, et al. PLoS One, 2013. PMID 23696892, Free PMC Article
    4. Spatial restriction of receptor tyrosine kinase activity through a polarized endocytic cycle controls border cell migration. Assaker G, et al. Proc Natl Acad Sci U S A, 2010 Dec 28. PMID 21149700, Free PMC Article
    5. Low FoxO expression in Drosophila somatosensory neurons protects dendrite growth under nutrient restriction. Poe AR, et al. Elife, 2020 May 19. PMID 32427101, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. found that rab proteins, Rab5 and RabX4, are required for the internalization of TRPL into the cell body
      Title: The Drosophila TRPL ion channel shares a Rab-dependent translocation pathway with rhodopsin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rab protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recycling endosome HDA PubMed 
    located_in synapse HDA PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RabX4
    Names
    CG31118-PA
    RabX4-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24826665..24828409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170170.3 → NP_733043.1  RabX4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733043.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VC31
      Related
      FBpp0084111
      Conserved Domains (1) summary
      smart00175
      Location:9 → 170
      RAB; Rab subfamily of small GTPases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VC31 Q9VC31

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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