U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    SYK spleen associated tyrosine kinase [ Gallus gallus (chicken) ]

    Gene ID: 427272, updated on 10-Oct-2024

    Summary

    Go to the top of the page Help
    Symbol
    SYKprovided by CGNC
    Full Name
    spleen associated tyrosine kinaseprovided by CGNC
    Primary source
    CGNC:53036
    See related
    Ensembl:ENSGALG00010009340
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SYK in Genome Data Viewer
    Location:
    chromosome: Z
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (44660428..44712213)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (44660428..44712213)

    Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101748847 Neighboring gene uncharacterized LOC121108570 Neighboring gene DIRAS family GTPase 2 Neighboring gene tubulin polymerization promoting protein family member 2 Neighboring gene AU RNA binding methylglutaconyl-CoA hydratase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Two closely spaced tyrosines regulate NFAT signaling in B cells via Syk association with Vav. Chen CH, et al. Mol Cell Biol, 2011 Jul. PMID 21606197, Free PMC Article
    2. Generation of an analog-sensitive Syk tyrosine kinase for the study of signaling dynamics from the B cell antigen receptor. Oh H, et al. J Biol Chem, 2007 Nov 16. PMID 17913708
    3. Nonredundant roles of Src-family kinases and Syk in the initiation of B-cell antigen receptor signaling. Stepanek O, et al. J Immunol, 2013 Feb 15. PMID 23335753
    4. Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases. Chung SC, et al. J Cell Biol, 2007 Apr 23. PMID 17452533, Free PMC Article
    5. Bruton's tyrosine kinase is essential for hydrogen peroxide-induced calcium signaling. Qin S, et al. Biochemistry, 2001 Jul 10. PMID 11434777

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters
      Title: The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters.
    2. Analysis of controlled B cell receptor triggering ex vivo and on primary murine B cells reveals that Src family kinases are required for signal initiation and Syk activation.
      Title: Nonredundant roles of Src-family kinases and Syk in the initiation of B-cell antigen receptor signaling.
    3. Results suggest that the uncommon recognition determinant of two closely spaced tyrosines is a limiting factor in NFAT signaling via Syk association with Vav1.
      Title: Two closely spaced tyrosines regulate NFAT signaling in B cells via Syk association with Vav.
    4. In hydrogen peroxide-stimulated DT40 cells, BLNK is phosphorylated by Syk and not by Btk.
      Title: Bruton's tyrosine kinase is essential for hydrogen peroxide-induced calcium signaling.
    5. Microarray analysis of SCA-2 induced bursal cells showed SYK to be among the under-expressed genes and this was validated with qRT-PCR.
      Title: Cloning and functional characterization of chicken stem cell antigen 2.
    6. Syk tyrosine kinase has a role in signaling dynamics of the B cell antigen receptor
      Title: Generation of an analog-sensitive Syk tyrosine kinase for the study of signaling dynamics from the B cell antigen receptor.
    7. The simultaneous but not the independent suppression of Lyn and Syk expression prevents the activation of Ca2+-release activated Ca2+ current without interfering with thapsigargin-sensitive Ca(2+) store release in DT40 B lymphocyte cells.
      Title: Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in macrophage activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neutrophil activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of alpha-beta T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of mast cell degranulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of platelet aggregation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extrinsic component of cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    tyrosine-protein kinase SYK
    Names
    spleen tyrosine kinase
    NP_001026601.2
    XP_015135783.1
    XP_015135784.1
    XP_046791077.1
    XP_046791078.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031430.2 → NP_001026601.2  tyrosine-protein kinase SYK

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000094
      UniProtKB/Swiss-Prot
      F1N9Y5, Q5ZJ91
      UniProtKB/TrEMBL
      A0A8V0Y9Z4
      Related
      ENSGALP00010012784.1, ENSGALT00010022248.1
      Conserved Domains (3) summary
      cd05116
      Location:353 → 609
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      44660428..44712213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015280297.4 → XP_015135783.1  tyrosine-protein kinase SYK isoform X1

      UniProtKB/TrEMBL
      A0A0A0MQ53, A0A8V0Y1F7
      Related
      ENSGALP00010012791.1, ENSGALT00010022258.1
      Conserved Domains (4) summary
      cd05116
      Location:376 → 632
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:371 → 627
      Pkinase_Tyr; Protein tyrosine kinase

    2. XM_015280298.4 → XP_015135784.1  tyrosine-protein kinase SYK isoform X1

      UniProtKB/TrEMBL
      A0A0A0MQ53, A0A8V0Y1F7
      Conserved Domains (4) summary
      cd05116
      Location:376 → 632
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12 → 115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163 → 261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:371 → 627
      Pkinase_Tyr; Protein tyrosine kinase

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      44660428..44712213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046935121.1 → XP_046791077.1  tyrosine-protein kinase SYK isoform X1

      UniProtKB/TrEMBL
      A0A0A0MQ53

    2. XM_046935122.1 → XP_046791078.1  tyrosine-protein kinase SYK isoform X1

      UniProtKB/TrEMBL
      A0A0A0MQ53
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1N9Y5.2 GenPept UniProtKB/Swiss-Prot:F1N9Y5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.