PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: PRKAA1provided by CGNC
Full Name: protein kinase AMP-activated catalytic subunit alpha 1provided by CGNC
Primary source: CGNC:53011
See related: Ensembl:ENSGALG00010014397
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: Z

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	Z	NC_052572.1 (13424099..13445029, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	Z	NC_059536.1 (13424099..13445029, complement)

Chromosome Z - NC_052572.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

glucocorticoids affected liver AMPK and the bile acid synthesis signal pathway, and AMPK might be involved in the glucocorticoid effect of liver bile acid synthesis.
Title: Effects of glucocorticoids on lipid metabolism and AMPK in broiler chickens' liver.
Cd induced the deregulation of miR-33-AMPK axis led to BNIP3-dependent autophagy in chicken spleen through AKT/mTOR and HSP70-NF-kappaB/JNK signal pathways.
Title: Cadmium induces BNIP3-dependent autophagy in chicken spleen by modulating miR-33-AMPK axis.
AMPKalpha1, AMPKalpha2 and PPARalpha were significantly increased in the animals exposed to cold temperatures.
Title: Effect of cold stress on expression of AMPKalpha-PPARalpha pathway and inflammation genes.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 5'-AMP-activated protein kinase catalytic subunit alpha-1

Names: 5'-AMP-activated protein kinase alpha-1 catalytic subunit; protein kinase, AMP-activated, alpha 1 catalytic subunit

NP_001034692.1

EC 2.7.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039603.2 → NP_001034692.1 5'-AMP-activated protein kinase catalytic subunit alpha-1

See identical proteins and their annotated locations for NP_001034692.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000089

UniProtKB/TrEMBL

E1C811, Q2PUH1

Related

ENSGALP00010020327.1, ENSGALT00010034633.1

Conserved Domains (4) summary

cd12199
Location:405 → 558

AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit

smart00220
Location:28 → 280

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14403
Location:297 → 361

UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)

cd14079
Location:25 → 280

STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

13424099..13445029 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

13424099..13445029 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)