PRXL2A peroxiredoxin like 2A [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: PRXL2Aprovided by CGNC
Official Full Name: peroxiredoxin like 2Aprovided by CGNC
Primary source: CGNC:1725
See related: Ensembl:ENSGALG00010010967
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: PAMM; FAM213A; SELENOU; C10ORF58; C6H10orf58
Summary: The protein encoded by this gene belongs to a subfamily of FAM213A/selenoprotein U (SelU), within a peroxiredoxin-like FAM213 superfamily. SelU is unusual in that it has restricted phylogenetic distribution in vertebrates, such as in chicken and fish. Other vertebrate members of this family, including mammals, contain cysteine-containing homologues. SelU proteins contain UxxC (U for selenocysteine and C for cysteine) motif in place of the catalytic CxxC motif found in cysteine-containing homologues. The latter function as redox regulatory proteins, suggesting a similar role for SelU proteins. Like majority of selenoproteins, SelU contains a single selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs in vertebrates contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	6	NC_052537.1 (5066999..5078169, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	6	NC_052578.1 (4951690..4962890, complement)

Chromosome 6 - NC_052537.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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General protein information

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Preferred Names: selenoprotein U

Names: Protein PAMM; UPF0765 protein C10orf58 homolog; family with sequence similarity 213 member A; peroxiredoxin (PRX)-like 2 activated in M-CSF stimulated monocytes; peroxiredoxin-like 2 activated in M-CSF stimulated monocytes; redox-regulatory protein FAM213A; redox-regulatory protein PAMM

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001193518.2 → NP_001180447.1 selenoprotein U

See identical proteins and their annotated locations for NP_001180447.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript derived from an upstream promoter. Variants 1 and 2 encode the same selenoprotein.

Source sequence(s)

JAENSK010000227

UniProtKB/Swiss-Prot

Q5ZI34

UniProtKB/TrEMBL

A0A0F6YFH3, A0A1D5PW05

Related

ENSGALP00010014887.1, ENSGALT00010026263.1

Conserved Domains (1) summary

cd02970
Location:49 → 201

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_001193519.3 → NP_001180448.1 selenoprotein U

See identical proteins and their annotated locations for NP_001180448.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate 5' non-coding exon derived from a downstream promoter, compared to variant 1. Variants 1 and 2 encode the same selenoprotein.

Source sequence(s)

JAENSK010000227

UniProtKB/Swiss-Prot

Q5ZI34

UniProtKB/TrEMBL

A0A0F6YFH3, A0A1D5PW05

Conserved Domains (1) summary

cd02970
Location:49 → 201

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

5066999..5078169 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

4951690..4962890 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NR_027494.1: Suppressed sequence

Description

NR_027494.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
NR_027495.1: Suppressed sequence

Description

NR_027495.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.