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    PDE5A phosphodiesterase 5A [ Gallus gallus (chicken) ]

    Gene ID: 422677, updated on 10-Oct-2024

    Summary

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    Symbol
    PDE5Aprovided by CGNC
    Full Name
    phosphodiesterase 5Aprovided by CGNC
    Primary source
    CGNC:9082
    See related
    Ensembl:ENSGALG00010005499
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    PDE5
    Orthologs
    human mouse all
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    Genomic context

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    See PDE5A in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (54091536..54224936)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (54091596..54224987)

    Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene mitotic arrest deficient 2 like 1 Neighboring gene ribosomal protein L7 like 1 Neighboring gene uncharacterized LOC107051713 Neighboring gene uncharacterized LOC107051795 Neighboring gene fatty acid binding protein 2 Neighboring gene ubiquitin specific peptidase 53 Neighboring gene serine/arginine repetitive matrix protein 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6. Cahill KB, et al. J Biol Chem, 2012 Nov 30. PMID 23033484, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 3',5'-cyclic-GMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cGMP-specific 3',5'-cyclic phosphodiesterase
    Names
    phosphodiesterase 5
    phosphodiesterase 5A, cGMP-specific
    NP_001385040.1
    NP_001385041.1
    NP_001385042.1
    NP_001385043.1
    NP_001385044.1
    NP_001385045.1
    XP_015131854.1
    XP_046772112.1
    XP_046772113.1
    XP_046796102.1
    XP_046796103.1
    XP_046796104.1
    XP_046796105.1
    XP_046796106.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398111.1 → NP_001385040.1  cGMP-specific 3',5'-cyclic phosphodiesterase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000074
      UniProtKB/TrEMBL
      A0A8V0XHV0
      Related
      ENSGALP00010007719.1, ENSGALT00010013157.1
      Conserved Domains (2) summary
      smart00065
      Location:146 → 303
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:593 → 828
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. NM_001398112.1 → NP_001385041.1  cGMP-specific 3',5'-cyclic phosphodiesterase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000074
      Conserved Domains (2) summary
      smart00065
      Location:146 → 303
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:590 → 825
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    3. NM_001398113.1 → NP_001385042.1  cGMP-specific 3',5'-cyclic phosphodiesterase isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000074
      UniProtKB/TrEMBL
      A0A8V0XS13
      Related
      ENSGALP00010007717.1, ENSGALT00010013155.1
      Conserved Domains (2) summary
      smart00065
      Location:120 → 277
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:567 → 802
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    4. NM_001398114.1 → NP_001385043.1  cGMP-specific 3',5'-cyclic phosphodiesterase isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000074
      UniProtKB/TrEMBL
      A0A8V0XPB7
      Related
      ENSGALP00010007721.1, ENSGALT00010013159.1
      Conserved Domains (2) summary
      smart00065
      Location:119 → 276
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:566 → 801
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    5. NM_001398115.1 → NP_001385044.1  cGMP-specific 3',5'-cyclic phosphodiesterase isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000074
      Conserved Domains (2) summary
      smart00065
      Location:120 → 277
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      cd00077
      Location:564 → 739
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    6. NM_001398116.1 → NP_001385045.1  cGMP-specific 3',5'-cyclic phosphodiesterase isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000074
      UniProtKB/TrEMBL
      A0A8V0XPB2
      Related
      ENSGALP00010007716.1, ENSGALT00010013154.1
      Conserved Domains (2) summary
      smart00065
      Location:114 → 271
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:561 → 796
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      54091536..54224936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046940149.1 → XP_046796105.1  cGMP-specific 3',5'-cyclic phosphodiesterase isoform X4

    2. XM_046940146.1 → XP_046796102.1  cGMP-specific 3',5'-cyclic phosphodiesterase isoform X3

      UniProtKB/TrEMBL
      A0A8V0XHV0

    3. XM_046940147.1 → XP_046796103.1  cGMP-specific 3',5'-cyclic phosphodiesterase isoform X3

      UniProtKB/TrEMBL
      A0A8V0XHV0

    4. XM_046940148.1 → XP_046796104.1  cGMP-specific 3',5'-cyclic phosphodiesterase isoform X3

      UniProtKB/TrEMBL
      A0A8V0XHV0

    5. XM_046940150.1 → XP_046796106.1  cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1

      UniProtKB/TrEMBL
      A0A8V0XPB7

    6. XM_015276368.4 → XP_015131854.1  cGMP-specific 3',5'-cyclic phosphodiesterase isoform X2

      UniProtKB/TrEMBL
      S4SCC1
      Related
      ENSGALP00010007715.1, ENSGALT00010013153.1
      Conserved Domains (2) summary
      smart00065
      Location:110 → 267
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:557 → 788
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      54091596..54224987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046916156.1 → XP_046772112.1  cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1

      UniProtKB/TrEMBL
      A0A8V0XPB7

    2. XM_046916157.1 → XP_046772113.1  cGMP-specific 3',5'-cyclic phosphodiesterase isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001319020.1: Suppressed sequence

      Description
      NM_001319020.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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