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    TyrRII Tyramine receptor II [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42135, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TyrRIIprovided by FlyBase
    Official Full Name
    Tyramine receptor IIprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038541
    Locus tag
    Dmel_CG16766
    See related
    AllianceGenome:FB:FBgn0038541
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0170980.124; anon-WO0170980.125; CG16766; DmCG16766; Dmel\CG16766; TAR3; TyRII; TyrR3; tyrRII; TyrRIII
    Summary
    Enables tyramine receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; cellular response to amine stimulus; and tyramine signaling pathway. Is integral component of plasma membrane. Is expressed in several structures, including embryonic/larval hypodermal muscle cell; epithelial tube; ganglia; gut section; and reproductive system. Orthologous to human HRH2 (histamine receptor H2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See TyrRII in Genome Data Viewer
    Location:
    90C2-90C2; 3-61 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17736611..17747470)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13562333..13573192)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat-containing G protein-coupled receptor 1 Neighboring gene uncharacterized protein Neighboring gene Tyramine receptor Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of multiple functional receptors for tyramine on an insect secretory epithelium. Zhang H, et al. Sci Rep, 2017 Dec. PMID 28279025, Free PMC Article
    2. A comparison of the signalling properties of two tyramine receptors from Drosophila. Bayliss A, et al. J Neurochem, 2013 Apr. PMID 23356740
    3. A new family of insect tyramine receptors. Cazzamali G, et al. Biochem Biophys Res Commun, 2005 Dec 16. PMID 16274665
    4. A neuronal mechanism controlling the choice between feeding and sexual behaviors in Drosophila. Cheriyamkunnel SJ, et al. Curr Biol, 2021 Oct 11. PMID 34358444, Free PMC Article
    5. Octopamine and Tyramine Contribute Separately to the Counter-Regulatory Response to Sugar Deficit in Drosophila. Damrau C, et al. Front Syst Neurosci, 2017. PMID 29379421, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled amine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled amine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tyramine receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to amine stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tyramine signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tyramine signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyramine receptor II
    Names
    CG16766-PA
    CG16766-PB
    CG16766-PC
    CG16766-PD
    TyrRII-PA
    TyrRII-PB
    TyrRII-PC
    TyrRII-PD
    tyramine receptor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17736611..17747470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300451.1 → NP_001287380.1  tyramine receptor II, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287380.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEG2
      Conserved Domains (2) summary
      pfam00001
      Location:91 → 277
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:82 → 212
      7tm_4; Olfactory receptor

    2. NM_001275754.2 → NP_001262683.1  tyramine receptor II, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262683.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEG2
      Conserved Domains (2) summary
      pfam00001
      Location:91 → 277
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:82 → 212
      7tm_4; Olfactory receptor

    3. NM_001275753.1 → NP_001262682.1  tyramine receptor II, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262682.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEG2
      Conserved Domains (2) summary
      pfam00001
      Location:91 → 277
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:82 → 212
      7tm_4; Olfactory receptor

    4. NM_142394.2 → NP_650651.1  tyramine receptor II, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650651.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEG2
      Related
      FBpp0082936
      Conserved Domains (2) summary
      pfam00001
      Location:91 → 277
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:82 → 212
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VEG2 Q9VEG2

    Gene LinkOut

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