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    Lgr1 Leucine-rich repeat-containing G protein-coupled receptor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42133, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Lgr1provided by FlyBase
    Official Full Name
    Leucine-rich repeat-containing G protein-coupled receptor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0016650
    Locus tag
    Dmel_CG7665
    See related
    AllianceGenome:FB:FBgn0016650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7665; DLGR-1; dLGR1; DLGR1; Dmel\CG7665; Fsh; FSH; Fsh R; FSH-TSH; Fsh/CG7665; LGR1; LH/CG receptor; RH44949p; TSH
    Summary
    Enables G protein-coupled receptor activity; hormone binding activity; and protein-hormone receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Is integral component of plasma membrane. Is expressed in dorsal closure embryo and gut section. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; Leydig cell tumor; congenital nongoitrous hypothyroidism 1; familial male-limited precocious puberty; and gonadal disease (multiple). Orthologous to several human genes including FSHR (follicle stimulating hormone receptor) and LHCGR (luteinizing hormone/choriogonadotropin receptor). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Lgr1 in Genome Data Viewer
    Location:
    90C2-90C2; 3-61 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17725777..17733207)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13551499..13558929)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Peroxinectin-like Neighboring gene Autophagy-related 8b Neighboring gene uncharacterized protein Neighboring gene Tyramine receptor II

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning, genomic organization, and developmental regulation of a novel receptor from Drosophila melanogaster structurally related to members of the thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone/choriogonadotropin receptor family from mammals. Hauser F, et al. J Biol Chem, 1997 Jan 10. PMID 8995395
    2. Molecular cloning, genomic organization, developmental regulation, and a knock-out mutant of a novel leu-rich repeats-containing G protein-coupled receptor (DLGR-2) from Drosophila melanogaster. Eriksen KK, et al. Genome Res, 2000 Jul. PMID 10899142, Free PMC Article
    3. Fsh-Pc-Sce complex mediates active transcription of Cubitus interruptus (Ci). Lv X, et al. J Mol Cell Biol, 2018 Oct 1. PMID 29432547
    4. Cloning, constitutive activity and expression profiling of two receptors related to relaxin receptors in Drosophila melanogaster. Van Hiel MB, et al. Peptides, 2015 Jun. PMID 25064813
    5. Neuroendocrine cells in Drosophila melanogaster producing GPA2/GPB5, a hormone with homology to LH, FSH and TSH. Sellami A, et al. Gen Comp Endocrinol, 2011 Feb 1. PMID 21118692

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fsh is a positive transcriptional regulator of Ci.Fsh physically interacts with Pc-Sce proteins.
      Title: Fsh-Pc-Sce complex mediates active transcription of Cubitus interruptus (Ci).
    2. Knockdown using RNA interference (RNAi) demonstrated that white pupa formation was severely suppressed in D. melanogaster lgr1 RNAi larvae.
      Title: Silencing D. melanogaster lgr1 impairs transition from larval to pupal stage.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hormone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables neuropeptide receptor activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables protein-hormone receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Leucine-rich repeat-containing G protein-coupled receptor 1
    Names
    CG7665-PA
    CG7665-PB
    Fsh-Tsh-like receptor
    Leu-rich repeats-containing G protein-coupled receptor
    Lgr1-PA
    Lgr1-PB
    glycoprotein A2/Glycoprotein B5 receptor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17725777..17733207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169777.2 → NP_732265.1  Leucine-rich repeat-containing G protein-coupled receptor 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732265.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q94979, Q9VEG4
      Related
      FBpp0082934
      Conserved Domains (3) summary
      sd00033
      Location:182 → 207
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00001
      Location:505 → 756
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam13855
      Location:258 → 313
      LRR_8; Leucine rich repeat

    2. NM_079669.3 → NP_524393.2  Leucine-rich repeat-containing G protein-coupled receptor 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524393.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q94979, Q9VEG4
      Related
      FBpp0082933
      Conserved Domains (3) summary
      sd00033
      Location:182 → 207
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00001
      Location:505 → 756
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam13855
      Location:258 → 313
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SX01 Q8SX01
    Q94979 Q94979
    Q9VEG4 Q9VEG4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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