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    MEA1 male-enhanced antigen 1 [ Homo sapiens (human) ]

    Gene ID: 4201, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MEA1provided by HGNC
    Official Full Name
    male-enhanced antigen 1provided by HGNC
    Primary source
    HGNC:HGNC:6986
    See related
    Ensembl:ENSG00000124733 MIM:143170; AllianceGenome:HGNC:6986
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HYS; MEA
    Summary
    Predicted to be involved in male gonad development and spermatogenesis. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 41.1), brain (RPKM 13.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MEA1 in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (43011143..43016886, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (42840241..42845985, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (42978881..42984624, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene CNPY3-GNMT readthrough Neighboring gene ReSE screen-validated silencer GRCh37_chr6:42935679-42935875 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:42938260-42939130 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:42939131-42939999 Neighboring gene glycine N-methyltransferase Neighboring gene peroxisomal biogenesis factor 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42946179-42947120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24582 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:42947525-42947721 Neighboring gene uncharacterized LOC124900215 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:42948960-42949178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24583 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17211 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17212 Neighboring gene Sharpr-MPRA regulatory region 14905 Neighboring gene protein phosphatase 2 regulatory subunit B'delta Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:42979352-42979852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24584 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42988913-42989644 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42989645-42990376 Neighboring gene kelch domain containing 3 Neighboring gene ribosomal RNA processing 36 Neighboring gene RNA, 7SL, cytoplasmic 403, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Male-enhanced antigen gene is phylogenetically conserved and expressed at late stages of spermatogenesis. Lau YF, et al. Proc Natl Acad Sci U S A, 1989 Nov. PMID 2813404, Free PMC Article
    2. Peas-Mea1-Ppp2r5d overlapping gene complex: a transposon mediated-gene formation in mammals. Ohinata Y, et al. DNA Res, 2003 Apr 30. PMID 12755172
    3. Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis. Ohinata Y, et al. Biol Reprod, 2002 Dec. PMID 12444059
    4. MITOL regulates phosphatidic acid-binding activity of RMDN3/PTPIP51. Ito N, et al. J Biochem, 2022 May 11. PMID 34964862
    5. Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms. Li J, et al. Mol Syst Biol, 2013 Nov 5. PMID 24189400, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in male gonad development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    male-enhanced antigen 1
    Names
    Male-enhanced antigen (H-Y structural gene)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318942.1 → NP_001305871.1  male-enhanced antigen 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2 and 3 both encode the same isoform (2).
      Source sequence(s)
      AL136304, BM450289, BM969076, HY039733
      Consensus CDS
      CCDS87405.1
      UniProtKB/TrEMBL
      A0A2R8Y7W8
      Related
      ENSP00000493896.1, ENST00000643776.1
      Conserved Domains (1) summary
      pfam06910
      Location:53 → 168
      MEA1; Male enhanced antigen 1 (MEA1)

    2. NM_001318943.1 → NP_001305872.1  male-enhanced antigen 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2 and 3 both encode the same isoform (2).
      Source sequence(s)
      AL136304, BM552852, BM969076, DB451970
      Consensus CDS
      CCDS87405.1
      UniProtKB/TrEMBL
      A0A2R8Y7W8
      Related
      ENSP00000494198.1, ENST00000645410.1
      Conserved Domains (1) summary
      pfam06910
      Location:53 → 168
      MEA1; Male enhanced antigen 1 (MEA1)

    3. NM_001363578.1 → NP_001350507.1  male-enhanced antigen 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AL136304
      Consensus CDS
      CCDS87406.1
      UniProtKB/TrEMBL
      A0A2R8Y6W5
      Related
      ENSP00000495612.1, ENST00000642748.1
      Conserved Domains (1) summary
      pfam06910
      Location:69 → 184
      MEA1; Male enhanced antigen 1 (MEA1)

    4. NM_014623.4 → NP_055438.1  male-enhanced antigen 1 isoform 1

      See identical proteins and their annotated locations for NP_055438.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (1) has a shorter and distinct N-terminus compared to isoform 3.
      Source sequence(s)
      AL136304, BM969076, BQ232807
      Consensus CDS
      CCDS4879.1
      UniProtKB/Swiss-Prot
      Q16626, Q5TC36, Q9BV01
      Related
      ENSP00000244711.3, ENST00000244711.4
      Conserved Domains (1) summary
      pfam06910
      Location:66 → 181
      MEA1; Male enhanced antigen 1 (MEA1)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      43011143..43016886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024446445.2 → XP_024302213.1  male-enhanced antigen 1 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Y7W8
      Related
      ENSP00000493661.1, ENST00000645375.1
      Conserved Domains (1) summary
      pfam06910
      Location:53 → 168
      MEA1; Male enhanced antigen 1 (MEA1)

    2. XM_047418782.1 → XP_047274738.1  male-enhanced antigen 1 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Y7W8
      Related
      ENSP00000496447.1, ENST00000642555.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      42840241..42845985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355451.1 → XP_054211426.1  male-enhanced antigen 1 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Y7W8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16626.2 GenPept UniProtKB/Swiss-Prot:Q16626

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