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    ZAP70 zeta chain of T cell receptor associated protein kinase [ Gallus gallus (chicken) ]

    Gene ID: 420086, updated on 10-Oct-2024

    Summary

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    Official Symbol
    ZAP70provided by CGNC
    Official Full Name
    zeta chain of T cell receptor associated protein kinaseprovided by CGNC
    Primary source
    CGNC:1027
    See related
    Ensembl:ENSGALG00010028550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See ZAP70 in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 28 NC_052559.1 (2237029..2258306)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 28 NC_052600.1 (1803061..1824335)

    Chromosome 28 - NC_052559.1Genomic Context describing neighboring genes Neighboring gene myosin IF Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 10 Neighboring gene microRNA 6615 Neighboring gene nuclear factor interleukin-3-regulated protein-like Neighboring gene actin like 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Splenic gene expression profiling in White Leghorn layer inoculated with the Salmonella enterica serovar Enteritidis. Wu G, et al. Anim Genet, 2015 Dec. PMID 26358731
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extrinsic component of cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase ZAP-70
    Names
    zeta-chain (TCR) associated protein kinase 70kDa
    NP_001308485.1
    XP_040509466.1
    XP_046760529.1
    XP_046789721.1
    XP_046789722.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321556.2 → NP_001308485.1  tyrosine-protein kinase ZAP-70

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000375
      UniProtKB/TrEMBL
      A0A8V1AEL3
      Conserved Domains (3) summary
      cd09938
      Location:8 → 111
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10402
      Location:152 → 256
      SH2_C-SH2_Zap70; C-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70)
      cd05115
      Location:323 → 591
      PTKc_Zap-70; Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052559.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      2237029..2258306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040653532.2 → XP_040509466.1  tyrosine-protein kinase ZAP-70 isoform X1

      UniProtKB/TrEMBL
      A0A8V1AEL3
      Related
      ENSGALP00010042587.1, ENSGALT00010069145.1
      Conserved Domains (3) summary
      cd09938
      Location:8 → 111
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10402
      Location:152 → 256
      SH2_C-SH2_Zap70; C-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70)
      cd05115
      Location:323 → 591
      PTKc_Zap-70; Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa

    2. XM_046904573.1 → XP_046760529.1  tyrosine-protein kinase ZAP-70 isoform X1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052600.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      1803061..1824335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046933765.1 → XP_046789721.1  tyrosine-protein kinase ZAP-70 isoform X1

    2. XM_046933766.1 → XP_046789722.1  tyrosine-protein kinase ZAP-70 isoform X1

    Nucleotide Protein
    Heading Accession and Version

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    Molecular Biology Databases
    Research Materials