SSU72 SSU72 homolog, RNA polymerase II CTD phosphatase [Gallus gallus (chicken)] - Gene

Summary

Symbol: SSU72provided by CGNC
Full Name: SSU72 homolog, RNA polymerase II CTD phosphataseprovided by CGNC
Primary source: CGNC:50991
See related: Ensembl:ENSGALG00010020261
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	21	NC_052552.1 (2112196..2134219)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	21	NC_052593.1 (2143742..2165767)

Chromosome 21 - NC_052552.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that chicken Ssu72 plays positive roles in 3'-end formation of snRNAs and polyadenylated mRNAs, but negative roles in 3'- end formation of histone mRNAs, through dephosphorylation of both Ser5 and Ser7 of the carboxy-terminal domain.
Title: Vertebrate Ssu72 regulates and coordinates 3'-end formation of RNAs transcribed by RNA polymerase II.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in termination of RNA polymerase II transcription	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of mRNA cleavage and polyadenylation specificity factor complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Names: CTD phosphatase SSU72

NP_001007876.1

EC 3.1.3.16

NP_001384616.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007875.2 → NP_001007876.1 RNA polymerase II subunit A C-terminal domain phosphatase SSU72 isoform 1

See identical proteins and their annotated locations for NP_001007876.1

Status: VALIDATED

Source sequence(s)

JAENSK010000329

UniProtKB/Swiss-Prot

Q5ZJQ7

Related

ENSGALP00010028904.1, ENSGALT00010048900.1

Conserved Domains (1) summary

pfam04722
Location:6 → 194

Ssu72; Ssu72-like protein
NM_001397687.1 → NP_001384616.1 RNA polymerase II subunit A C-terminal domain phosphatase SSU72 isoform 2

Status: VALIDATED

Source sequence(s)

JAENSK010000329