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    MCF2 MCF.2 cell line derived transforming sequence [ Homo sapiens (human) ]

    Gene ID: 4168, updated on 14-Nov-2024

    Summary

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    Official Symbol
    MCF2provided by HGNC
    Official Full Name
    MCF.2 cell line derived transforming sequenceprovided by HGNC
    Primary source
    HGNC:HGNC:6940
    See related
    Ensembl:ENSG00000101977 MIM:311030; AllianceGenome:HGNC:6940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DBL; ARHGEF21
    Summary
    The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.[provided by RefSeq, Jan 2010]
    Expression
    Biased expression in adrenal (RPKM 10.3), testis (RPKM 7.9) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MCF2 in Genome Data Viewer
    Location:
    Xq27.1
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (139581770..139708167, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (137890836..138020159, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (138663929..138790326, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene steroid 5 alpha-reductase 1 pseudogene 1 Neighboring gene coagulation factor IX Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21035 Neighboring gene Sharpr-MPRA regulatory region 14619 Neighboring gene brain cytoplasmic RNA 1, pseudogene 1 Neighboring gene ATPase phospholipid transporting 11C Neighboring gene RNA, U6atac small nuclear 23, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Dbl oncogene expression in MCF-10 A epithelial cells disrupts mammary acinar architecture, induces EMT and angiogenic factor secretion. Vanni C, et al. Cell Cycle, 2015. PMID 25723869, Free PMC Article
    2. A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr. Ron D, et al. New Biol, 1991 Apr. PMID 2065022
    3. Human dbl proto-oncogene in 85 kb of xq26, and determination of the transcription initiation site. Palmieri G, et al. Gene, 2000 Jul 25. PMID 10925207
    4. Activation of a mcf.2 oncogene by deletion of amino-terminal coding sequences. Noguchi T, et al. Oncogene, 1988 Dec. PMID 2577874
    5. Chromosomal localization of DBL oncogene sequences. Tronick SR, et al. Genomics, 1989 Oct. PMID 2613238

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we elucidate a mechanism through which the DBL family members MCF2 and VAV1 act to drive drug resistance in human BRAFV600E-mutant melanoma cells
      Title: Src-Dependent DBL Family Members Drive Resistance to Vemurafenib in Human Melanoma.
    2. Results support a role for Dbl oncogene in mammary epithelial cell differentiation and transformation and suggest the relevance of GEF deregulation in tumor onset and progression.
      Title: Dbl oncogene expression in MCF-10 A epithelial cells disrupts mammary acinar architecture, induces EMT and angiogenic factor secretion.
    3. Phosphoinositide 3-kinase C2beta regulates RhoA and the actin cytoskeleton through an interaction with Dbl
      Title: Phosphoinositide 3-kinase C2β regulates RhoA and the actin cytoskeleton through an interaction with Dbl.
    4. Dbl is regulated by hamartin through association with ezrin.
      Title: The tumor suppressor hamartin enhances Dbl protein transforming activity through interaction with ezrin.
    5. proto-oncogene dbl is not a major target for sporadic testicular germ cell tumors
      Title: Mutational analysis of proto-oncogene Dbl on Xq27 in testicular germ cell tumors reveals a rare SNP in a patient with bilateral undescended testis.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia.
    7. Nm23-H1 can negatively regulate cell migration and tumor metastasis by modulating the activity of Cdc42 and possibly other Rho family members through interaction with Dbl-1
      Title: The suppressor of metastasis Nm23-H1 interacts with the Cdc42 Rho family member and the pleckstrin homology domain of oncoprotein Dbl-1 to suppress cell migration.
    8. Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain
      Title: Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain.
    9. These data suggest a mechanism whereby precise spatial guanine nucleotide exchange of Cdc42 by Dbl is dependent on functional ERM proteins and is important for directional cell migration.
      Title: Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42.
    10. data describe 4 splicing variants of the human DBL (MCF-2) proto-oncogene that show different tissue distributions and guanine nucleotide exchange factor specificities
      Title: Alternative splicing variants of the human DBL (MCF-2) proto-oncogene.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dendrite development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of axonogenesis TAS
    Traceable Author Statement
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proto-oncogene DBL
    Names
    Oncogene MCF2 (oncogene DBL)
    proto-oncogene MCF-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016439.2 RefSeqGene

      Range
      5000..131397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001099855.2 → NP_001093325.1  proto-oncogene DBL isoform a

      See identical proteins and their annotated locations for NP_001093325.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform c.
      Source sequence(s)
      AL033403, AL117234, DC298193
      Consensus CDS
      CCDS48175.1
      UniProtKB/TrEMBL
      A0A2X0SZ10
      Related
      ENSP00000397055.1, ENST00000414978.5
      Conserved Domains (5) summary
      smart00516
      Location:5 → 145
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:556 → 733
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:285 → 476
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00169
      Location:783 → 868
      PH; PH domain
      cl17171
      Location:740 → 871
      PH-like; Pleckstrin homology-like domain

    2. NM_001171876.2 → NP_001165347.1  proto-oncogene DBL isoform c

      See identical proteins and their annotated locations for NP_001165347.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
      Source sequence(s)
      AK316416, AL033403, AL117234, DC298193
      Consensus CDS
      CCDS55517.1
      UniProtKB/TrEMBL
      A0A2X0SZ10
      Related
      ENSP00000430276.1, ENST00000519895.6
      Conserved Domains (5) summary
      smart00516
      Location:5 → 145
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:572 → 749
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:285 → 476
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00169
      Location:799 → 884
      PH; PH domain
      cl17171
      Location:756 → 887
      PH-like; Pleckstrin homology-like domain

    3. NM_001171877.2 → NP_001165348.1  proto-oncogene DBL isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks several exons compared to variant 3. The resulting isoform (d) has shorter and distinct N- and C-termini and lacks two segments compared to isoform c.
      Source sequence(s)
      AL033403
      Consensus CDS
      CCDS55514.1
      UniProtKB/TrEMBL
      B2R9S6
      Related
      ENSP00000438155.1, ENST00000536274.5
      Conserved Domains (5) summary
      cd00160
      Location:457 → 634
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:186 → 377
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00169
      Location:684 → 769
      PH; PH domain
      pfam13716
      Location:2 → 91
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
      cl17171
      Location:641 → 772
      PH-like; Pleckstrin homology-like domain

    4. NM_001171878.2 → NP_001165349.1  proto-oncogene DBL isoform e

      See identical proteins and their annotated locations for NP_001165349.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks several exons compared to variant 3. The resulting isoform (e) has shorter and distinct N- and C-termini and lacks a segment compared to isoform c.
      Source sequence(s)
      AL033403
      Consensus CDS
      CCDS55515.1
      UniProtKB/TrEMBL
      B2R9S6
      Related
      ENSP00000359605.4, ENST00000370573.8
      Conserved Domains (5) summary
      cd00160
      Location:496 → 673
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:225 → 416
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00169
      Location:723 → 808
      PH; PH domain
      cl15787
      Location:20 → 85
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      cl17171
      Location:680 → 811
      PH-like; Pleckstrin homology-like domain

    5. NM_001171879.2 → NP_001165350.1  proto-oncogene DBL isoform f

      See identical proteins and their annotated locations for NP_001165350.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (f) has a shorter and distinct N-terminus compared to isoform c.
      Source sequence(s)
      AL033403
      Consensus CDS
      CCDS55516.1
      UniProtKB/TrEMBL
      B2R9S6
      Related
      ENSP00000342204.6, ENST00000338585.6
      Conserved Domains (5) summary
      cd00160
      Location:512 → 689
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:225 → 416
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00169
      Location:739 → 824
      PH; PH domain
      cl15787
      Location:20 → 85
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      cl17171
      Location:696 → 827
      PH-like; Pleckstrin homology-like domain

    6. NM_005369.6 → NP_005360.3  proto-oncogene DBL isoform b

      See identical proteins and their annotated locations for NP_005360.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (b) lacks an internal segment and has a shorter and distinct N-terminus compared to isoform c.
      Source sequence(s)
      AL033403
      Consensus CDS
      CCDS14667.1
      UniProtKB/Swiss-Prot
      B7Z3Y5, B7Z869, B7ZAV1, E9PH77, F5H091, P10911, P14919, Q5JYJ2, Q5JYJ3, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3
      UniProtKB/TrEMBL
      B2R9S6
      Related
      ENSP00000359608.4, ENST00000370576.9
      Conserved Domains (5) summary
      cd00160
      Location:496 → 673
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:225 → 416
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00169
      Location:723 → 808
      PH; PH domain
      cl15787
      Location:20 → 85
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      cl17171
      Location:680 → 811
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      139581770..139708167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442112.1 → XP_047298068.1  proto-oncogene DBL isoform X5

    2. XM_005262413.5 → XP_005262470.1  proto-oncogene DBL isoform X1

      UniProtKB/TrEMBL
      A0A2U3TZL4
      Related
      ENSP00000427745.2, ENST00000520602.6
      Conserved Domains (5) summary
      smart00516
      Location:48 → 188
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:615 → 792
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:328 → 519
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00169
      Location:842 → 927
      PH; PH domain
      cl17171
      Location:799 → 930
      PH-like; Pleckstrin homology-like domain

    3. XM_017029529.2 → XP_016885018.1  proto-oncogene DBL isoform X2

      UniProtKB/TrEMBL
      A0A2U3TZL4
      Conserved Domains (5) summary
      smart00516
      Location:48 → 188
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:615 → 792
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:328 → 519
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00169
      Location:842 → 927
      PH; PH domain
      cl17171
      Location:799 → 930
      PH-like; Pleckstrin homology-like domain

    4. XM_011531339.3 → XP_011529641.1  proto-oncogene DBL isoform X4

      See identical proteins and their annotated locations for XP_011529641.1

      UniProtKB/TrEMBL
      A0A2X0SZ10
      Conserved Domains (5) summary
      smart00516
      Location:5 → 145
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:572 → 749
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:285 → 476
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00169
      Location:799 → 884
      PH; PH domain
      cl17171
      Location:756 → 887
      PH-like; Pleckstrin homology-like domain

    5. XM_047442111.1 → XP_047298067.1  proto-oncogene DBL isoform X3

    6. XM_017029531.2 → XP_016885020.1  proto-oncogene DBL isoform X4

      UniProtKB/TrEMBL
      A0A2X0SZ10
      Conserved Domains (5) summary
      smart00516
      Location:5 → 145
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:572 → 749
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:285 → 476
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00169
      Location:799 → 884
      PH; PH domain
      cl17171
      Location:756 → 887
      PH-like; Pleckstrin homology-like domain

    7. XM_047442113.1 → XP_047298069.1  proto-oncogene DBL isoform X7

    8. XM_017029532.3 → XP_016885021.1  proto-oncogene DBL isoform X6

      UniProtKB/TrEMBL
      B2R9S6

    9. XM_047442114.1 → XP_047298070.1  proto-oncogene DBL isoform X8

      Related
      ENSP00000405848.1, ENST00000446225.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      137890836..138020159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327083.1 → XP_054183058.1  proto-oncogene DBL isoform X2

    2. XM_054327089.1 → XP_054183064.1  proto-oncogene DBL isoform X7

    3. XM_054327088.1 → XP_054183063.1  proto-oncogene DBL isoform X6

    4. XM_054327087.1 → XP_054183062.1  proto-oncogene DBL isoform X5

    5. XM_054327082.1 → XP_054183057.1  proto-oncogene DBL isoform X1

    6. XM_054327085.1 → XP_054183060.1  proto-oncogene DBL isoform X4

    7. XM_054327084.1 → XP_054183059.1  proto-oncogene DBL isoform X3

    8. XM_054327086.1 → XP_054183061.1  proto-oncogene DBL isoform X4

    9. XM_054327090.1 → XP_054183065.1  proto-oncogene DBL isoform X8

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10911.3 GenPept UniProtKB/Swiss-Prot:P10911

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