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    ASIP agouti signaling protein [ Sus scrofa (pig) ]

    Gene ID: 414439, updated on 5-Mar-2024

    Summary

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    Gene symbol
    ASIP
    Gene description
    agouti signaling protein
    See related
    Ensembl:ENSSSCG00000053652
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    agouti
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human mouse all
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    Genomic context

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    See ASIP in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 17 NC_010459.5 (37542615..37718787)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 17 NC_010459.4 (42538122..42686968)

    Chromosome 17 - NC_010459.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110257469 Neighboring gene RALY heterogeneous nuclear ribonucleoprotein Neighboring gene eukaryotic translation initiation factor 2 subunit beta Neighboring gene adenosylhomocysteinase Neighboring gene itchy E3 ubiquitin protein ligase Neighboring gene 40S ribosomal protein S27-like pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. The mutation causing the black-and-tan pigmentation phenotype of Mangalitza pigs maps to the porcine ASIP locus but does not affect its coding sequence. Drögemüller C, et al. Mamm Genome, 2006 Jan. PMID 16416091
    2. Polymorphism in the porcine agouti signalling protein (ASIP) gene. Kim TH, et al. Anim Genet, 2004 Oct. PMID 15373753
    3. Genomic structure and nucleotide polymorphisms of the porcine agouti signalling protein gene (ASIP). Leeb T, et al. Anim Genet, 2000 Oct. PMID 11105218
    4. Analysis of the MC1R, KIT and ASIP loci in Chinese and European pigs. Shi KR, et al. Anim Genet, 2006 Jun. PMID 16734703

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutational analysis of the ASIP loci in relation to coat color.
      Title: Analysis of the MC1R, KIT and ASIP loci in Chinese and European pigs.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables melanocortin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables neuropeptide hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hormone-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in melanosome organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of melanin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    agouti-signaling protein
    Names
    ASP
    agouti signaling protein, nonagouti homolog
    agouti signalling protein
    agouti singaling protein
    agouti switch protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001648.4 → NP_001001648.1  agouti-signaling protein isoform 1A precursor

      See identical proteins and their annotated locations for NP_001001648.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ634674
      UniProtKB/Swiss-Prot
      Q4R1H8, Q5QJU6, Q6ZYM3
      UniProtKB/TrEMBL
      C8C9X0, I3W8V4
      Conserved Domains (1) summary
      smart00792
      Location:16 → 127
      Agouti; Agouti protein

    2. NM_001011646.1 → NP_001011646.1  agouti-signaling protein isoform 1A' precursor

      See identical proteins and their annotated locations for NP_001011646.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ634675
      UniProtKB/Swiss-Prot
      Q4R1H8, Q5QJU6, Q6ZYM3
      UniProtKB/TrEMBL
      C8C9X0, I3W8V4
      Conserved Domains (1) summary
      smart00792
      Location:16 → 127
      Agouti; Agouti protein

    3. NM_001011647.1 → NP_001011647.1  agouti-signaling protein isoform 1A1A' precursor

      See identical proteins and their annotated locations for NP_001011647.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ634676
      UniProtKB/Swiss-Prot
      Q4R1H8, Q5QJU6, Q6ZYM3
      UniProtKB/TrEMBL
      C8C9X0, I3W8V4
      Conserved Domains (1) summary
      smart00792
      Location:16 → 127
      Agouti; Agouti protein

    4. NM_001011648.1 → NP_001011648.1  agouti-signaling protein isoform 1B precursor

      See identical proteins and their annotated locations for NP_001011648.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ634677
      UniProtKB/Swiss-Prot
      Q4R1H8, Q5QJU6, Q6ZYM3
      UniProtKB/TrEMBL
      C8C9X0, I3W8V4
      Conserved Domains (1) summary
      smart00792
      Location:16 → 127
      Agouti; Agouti protein

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010459.5 Reference Sscrofa11.1 Primary Assembly

      Range
      37542615..37718787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005672859.3 → XP_005672916.2  agouti-signaling protein isoform X1

      UniProtKB/Swiss-Prot
      Q4R1H8, Q5QJU6, Q6ZYM3
      UniProtKB/TrEMBL
      C8C9X0, I3W8V4
      Conserved Domains (1) summary
      smart00792
      Location:16 → 127
      Agouti; Agouti protein

    2. XM_021077312.1 → XP_020932971.1  agouti-signaling protein isoform X1

      UniProtKB/Swiss-Prot
      Q4R1H8, Q5QJU6, Q6ZYM3
      UniProtKB/TrEMBL
      C8C9X0, I3W8V4
      Conserved Domains (1) summary
      smart00792
      Location:16 → 127
      Agouti; Agouti protein

    3. XM_021077313.1 → XP_020932972.1  agouti-signaling protein isoform X1

      UniProtKB/Swiss-Prot
      Q4R1H8, Q5QJU6, Q6ZYM3
      UniProtKB/TrEMBL
      C8C9X0, I3W8V4
      Related
      ENSSSCP00000077513.1, ENSSSCT00000096631.1
      Conserved Domains (1) summary
      smart00792
      Location:16 → 127
      Agouti; Agouti protein

    4. XM_021077314.1 → XP_020932973.1  agouti-signaling protein isoform X1

      UniProtKB/Swiss-Prot
      Q4R1H8, Q5QJU6, Q6ZYM3
      UniProtKB/TrEMBL
      C8C9X0, I3W8V4
      Conserved Domains (1) summary
      smart00792
      Location:16 → 127
      Agouti; Agouti protein

    5. XM_013985281.2 → XP_013840735.2  agouti-signaling protein isoform X1

      UniProtKB/Swiss-Prot
      Q4R1H8, Q5QJU6, Q6ZYM3
      UniProtKB/TrEMBL
      C8C9X0, I3W8V4
      Conserved Domains (1) summary
      smart00792
      Location:16 → 127
      Agouti; Agouti protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZYM3.1 GenPept UniProtKB/Swiss-Prot:Q6ZYM3

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