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    MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 [ Sus scrofa (pig) ]

    Gene ID: 414382, updated on 17-Aug-2024

    Summary

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    Official Symbol
    MTHFD1provided by VGNC
    Official Full Name
    methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1provided by VGNC
    Primary source
    VGNC:VGNC:90450
    See related
    Ensembl:ENSSSCG00000002269
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Ubiquitous expression in liver (RPKM 59.3), kidney (RPKM 35.8) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See MTHFD1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 7 NC_010449.5 (88471317..88533690)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 7 NC_010449.4 (94832549..94894977)

    Chromosome 7 - NC_010449.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110261687 Neighboring gene 60S ribosomal protein L19 pseudogene Neighboring gene coiled-coil domain-containing protein 170-like Neighboring gene zinc finger and BTB domain containing 25 Neighboring gene A-kinase anchoring protein 5 Neighboring gene zinc finger and BTB domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
    2. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables formate-tetrahydrofolate ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables methenyltetrahydrofolate cyclohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C-1-tetrahydrofolate synthase, cytoplasmic
    Names
    formyltetrahydrofolate synthetase
    methenyltetrahydrofolate cyclohydrolase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010449.5 Reference Sscrofa11.1 Primary Assembly

      Range
      88471317..88533690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021099913.1 → XP_020955572.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X2

      UniProtKB/TrEMBL
      A0A8D1PUR2, A0A8D2BQD0
      Conserved Domains (2) summary
      PLN02759
      Location:309 → 963
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:6 → 294
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    2. XM_001924329.5 → XP_001924364.2  C-1-tetrahydrofolate synthase, cytoplasmic isoform X1

      See identical proteins and their annotated locations for XP_001924364.2

      UniProtKB/TrEMBL
      A0A4X1UGR4, A0A8D0LU86, F1SA74, K9IVE8
      Related
      ENSSSCP00000002464.3, ENSSSCT00000002527.5
      Conserved Domains (4) summary
      cd01080
      Location:120 → 292
      NAD_bind_m-THF_DH_Cyclohyd; NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:309 → 935
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:6 → 294
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:6 → 125
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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