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    CD86 CD86 molecule [ Bos taurus (domestic cattle) ]

    Gene ID: 414345, updated on 4-Oct-2024

    Summary

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    Official Symbol
    CD86provided by VGNC
    Official Full Name
    CD86 moleculeprovided by VGNC
    Primary source
    VGNC:VGNC:27051
    See related
    BGD:BT20202; Ensembl:ENSBTAG00000013118
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CD86 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (66544185..66610934)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132345641 Neighboring gene solute carrier family 15 member 2-like Neighboring gene immunoglobulin like domain containing receptor 1 Neighboring gene uncharacterized LOC132342118 Neighboring gene calcium sensing receptor Neighboring gene interferon-induced, double-stranded RNA-activated protein kinase-like Neighboring gene SRA stem-loop-interacting RNA-binding protein, mitochondrial-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CD80 and CD86, but not CD154, augment DNA vaccine-induced protection in experimental bovine tuberculosis. Maue AC, et al. Vaccine, 2004 Dec 21. PMID 15542201
    2. Expression of costimulatory molecules in the bovine corpus luteum. Cannon MJ, et al. Reprod Biol Endocrinol, 2007 Jan 31. PMID 17266770, Free PMC Article
    3. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    4. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in T cell costimulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    T-lymphocyte activation antigen CD86
    Names
    CD86 antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038017.2 → NP_001033106.1  T-lymphocyte activation antigen CD86

      Status: PROVISIONAL

      Source sequence(s)
      AJ291475, AY533858
      UniProtKB/TrEMBL
      A0A3Q1NCV9
      Related
      ENSBTAP00000069271.2, ENSBTAT00000066751.2
      Conserved Domains (2) summary
      smart00410
      Location:41 → 120
      IG_like; Immunoglobulin like
      cl11960
      Location:44 → 126
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      66544185..66610934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024995396.2 → XP_024851164.1  T-lymphocyte activation antigen CD86 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1NCV9
      Conserved Domains (1) summary
      cd16087
      Location:29 → 134
      IgV_CD86; Immunoglobulin variable domain (IgV) in CD86

    2. XM_024995417.2 → XP_024851185.1  T-lymphocyte activation antigen CD86 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1NCV9
      Conserved Domains (1) summary
      cd16087
      Location:22 → 127
      IgV_CD86; Immunoglobulin variable domain (IgV) in CD86

    3. XM_005201387.5 → XP_005201444.1  T-lymphocyte activation antigen CD86 isoform X4

      See identical proteins and their annotated locations for XP_005201444.1

      UniProtKB/TrEMBL
      Q1JPC5, Q9GL33
      Related
      ENSBTAP00000032224.2, ENSBTAT00000032289.3
      Conserved Domains (1) summary
      cd16087
      Location:35 → 140
      IgV_CD86; Immunoglobulin variable domain (IgV) in CD86

    4. XM_005201386.5 → XP_005201443.1  T-lymphocyte activation antigen CD86 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1NCV9
      Conserved Domains (2) summary
      smart00410
      Location:34 → 113
      IG_like; Immunoglobulin like
      cl11960
      Location:37 → 119
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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