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    Taf12 TBP-associated factor 12 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41406, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Taf12provided by FlyBase
    Official Full Name
    TBP-associated factor 12provided by FlyBase
    Primary source
    FLYBASE:FBgn0011290
    Locus tag
    Dmel_CG17358
    See related
    AllianceGenome:FB:FBgn0011290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17358; d28/22; Dmel\CG17358; dmTAF12; dTaf12; dTAF12; dTAF22; dTAF28; dTAFII30; dTAFII30 alpha; dTAF[[II]]30; dTAF[[II]]30alpha; dTAF[[II]]30alpha/22; p22; p28; T2DA_DROME; TAF; taf12; TAF12; Taf22; Taf28; TAF30a; Taf30alpha; TAF30alpha; TAF30alpha/28; TAF30alpha/28/22; Taf32; TAFII30alpha/22; TAF[II]30alpha; TAF[[II]]; TAF[[II]]230; Taf[[II]]30alpha; TAF[[II]]30alpha; TAF[[II]]30alpha/28 TAF[[II]]22; TAF[[II]]30alpha/28/22; TFIID; TFIID 22; TFIID 28; TFIID-p28
    Summary
    Enables protein homodimerization activity. Contributes to RNA polymerase II general transcription initiation factor activity. Involved in histone H3 acetylation. Located in nucleus. Part of SAGA complex and transcription factor TFIID complex. Is expressed in organism. Orthologous to human TAF12 (TATA-box binding protein associated factor 12). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Taf12 in Genome Data Viewer
    Location:
    86E15-86E15; 3-51 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11678386..11679690, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7504108..7505412, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Heme oxygenase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Activation of RNA polymerase II transcription. Berk AJ. Curr Opin Cell Biol, 1999 Jun. PMID 10395559
    2. X-ray crystallographic studies of eukaryotic transcription factors. Burley SK. Cold Spring Harb Symp Quant Biol, 1998. PMID 10384268
    3. The role of TAFs in RNA polymerase II transcription. Hahn S. Cell, 1998 Nov 25. PMID 9845358
    4. UV cross-linking identifies four polypeptides that require the TATA box to bind to the Drosophila hsp70 promoter. Gilmour DS, et al. Mol Cell Biol, 1990 Aug. PMID 2370864, Free PMC Article
    5. c-Jun binds the N terminus of human TAF(II)250 to derepress RNA polymerase II transcription in vitro. Lively TN, et al. J Biol Chem, 2001 Jul 6. PMID 11316804

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II general transcription initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables TBP-class protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAGA complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIID complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIID complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TBP-associated factor 12
    Names
    26kDa polypeptide
    CG17358-PA
    CG17358-PB
    CG17358-PD
    CG17358-PE
    TBP-associated factor
    TBP-associated factor 30kD subunit alpha
    Taf12-PA
    Taf12-PB
    Taf12-PD
    Taf12-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11678386..11679690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169421.3 → NP_731617.2  TBP-associated factor 12, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731617.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFN0
      Conserved Domains (1) summary
      cd07981
      Location:55 → 126
      TAF12; TATA Binding Protein (TBP) Associated Factor 12 (TAF12) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    2. NM_001275550.1 → NP_001262479.1  TBP-associated factor 12, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262479.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFN0
      Conserved Domains (1) summary
      cd07981
      Location:55 → 126
      TAF12; TATA Binding Protein (TBP) Associated Factor 12 (TAF12) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    3. NM_169420.2 → NP_731616.1  TBP-associated factor 12, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731616.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2Q1, P49905, Q26339, Q9VGK0
      Related
      FBpp0081916
      Conserved Domains (1) summary
      pfam03847
      Location:93 → 159
      TFIID_20kDa; Transcription initiation factor TFIID subunit A

    4. NM_079596.3 → NP_524320.1  TBP-associated factor 12, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524320.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2Q1, P49905, Q26339, Q9VGK0
      Related
      FBpp0081918
      Conserved Domains (1) summary
      pfam03847
      Location:93 → 159
      TFIID_20kDa; Transcription initiation factor TFIID subunit A
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFN0 A0A0B4KFN0
    P49905.1 P49905

    Gene LinkOut

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