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    Csk C-terminal Src kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41398, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Cskprovided by FlyBase
    Official Full Name
    C-terminal Src kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262081
    Locus tag
    Dmel_CG42317
    See related
    AllianceGenome:FB:FBgn0262081
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17309; CG32852; CG42317; csk; CSK; d-Csk; dcsk; dCsk; dCSK; DCsk; Dmel\CG42317; flik; l(3)j1D8; l(3)S017909; Src
    Old locus tag
    Dmel_CG17309; Dmel_CG32852
    Summary
    Enables non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including adherens junction maintenance; negative regulation of imaginal disc growth; and positive regulation of hippo signaling. Predicted to be located in cell-cell junction. Is expressed in salivary gland. Orthologous to several human genes including CSK (C-terminal Src kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Csk in Genome Data Viewer
    Location:
    86E13-86E13; 3-51 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11633278..11650706, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7459000..7476428, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44137 Neighboring gene Elongator complex protein 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C-terminal Src kinase (Csk) regulates the tricellular junction protein Gliotactin independent of Src. Samarasekera GDNG, et al. Mol Biol Cell, 2018 Jan 15. PMID 29167383, Free PMC Article
    2. A genetic screen for modifiers of the lats tumor suppressor gene identifies C-terminal Src kinase as a regulator of cell proliferation in Drosophila. Stewart RA, et al. Oncogene, 2003 Sep 25. PMID 14508523
    3. Interactions between normal and transformed epithelial cells: Their contributions to tumourigenesis. Hogan C, et al. Int J Biochem Cell Biol, 2011 Apr. PMID 21187160
    4. A role for the epithelial microenvironment at tumor boundaries: evidence from Drosophila and human squamous cell carcinomas. Vidal M, et al. Am J Pathol, 2010 Jun. PMID 20363916, Free PMC Article
    5. Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis. Pedraza LG, et al. Oncogene, 2004 Jun 10. PMID 15107833

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. C-terminal Src kinase (Csk) as a tyrosine kinase is responsible for regulating Gliotactin endocytosis. Increased Csk suppresses the Gliotactin overexpression phenotypes by increasing endocytosis. Loss of Csk causes Gliotactin to spread away from the Tricellular junctions.
      Title: C-terminal Src kinase (Csk) regulates the tricellular junction protein Gliotactin independent of Src.
    2. Csk and its SFK substrates impinge upon homeostatic control of NMJ function by regulating downstream expression or localization of FasII.
      Title: C-terminal Src Kinase Gates Homeostatic Synaptic Plasticity and Regulates Fasciclin II Expression at the Drosophila Neuromuscular Junction.
    3. dCsk is another upstream member of the network of genes that interact to regulate Wts and its effector Yki in the Hippo signaling pathway
      Title: Drosophila C-terminal Src kinase regulates growth via the Hippo signaling pathway.
    4. A functional link between cell polarity, the JAK/STAT signalling pathway and the Src kinases has been established in a whole organism.
      Title: Src kinases mediate the interaction of the apical determinant Bazooka/PAR3 with STAT92E and increase signalling efficiency in Drosophila ectodermal cells.
    5. Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis.
      Title: Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis.
    6. Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways
      Title: Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways.
    7. Results demonstrate that regulation of Src64 by Drosophila C-terminal-Src Kinase (Csk) contributes to the packaging of germline cysts by overlying somatic follicle cells during egg chamber formation.
      Title: Csk differentially regulates Src64 during distinct morphological events in Drosophila germ cells.
    8. C-terminal Src kinase (CSK) in Drosophila was identified in a genetic modifier screen for genes that interact with the lats tumor suppressor gene. CSK regulates cell proliferation and organ size.
      Title: A genetic screen for modifiers of the lats tumor suppressor gene identifies C-terminal Src kinase as a regulator of cell proliferation in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adherens junction maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial structure maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germarium-derived egg chamber formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of imaginal disc growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of hippo signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic plasticity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell-cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    C-terminal Src kinase
    Names
    C-Src kinase
    C-terminal-Src kinase
    CG42317-PF
    CG42317-PG
    CG42317-PH
    CG42317-PI
    CG42317-PJ
    CG42317-PK
    CG42317-PL
    Csk-PF
    Csk-PG
    Csk-PH
    Csk-PI
    Csk-PJ
    Csk-PK
    Csk-PL
    drosophila C-terminal Src kinase
    flik
    lethal (3) S017909
    lethal (3) j1D8
    NP_001262476.1
    NP_650097.2
    NP_731607.1
    NP_731608.1
    NP_731609.1
    NP_731611.2
    NP_788638.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11633278..11650706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169414.2 → NP_731607.1  C-terminal Src kinase, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731607.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NP28, Q7KSQ2
      Related
      FBpp0289774
      Conserved Domains (3) summary
      cd09937
      Location:351 → 448
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      smart00221
      Location:471 → 715
      STYKc; Protein kinase; unclassified specificity
      cd05039
      Location:464 → 718
      PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases

    2. NM_169418.3 → NP_731611.2  C-terminal Src kinase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731611.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INJ8
      Conserved Domains (3) summary
      cd09937
      Location:680 → 777
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      smart00221
      Location:800 → 1044
      STYKc; Protein kinase; unclassified specificity
      cd05039
      Location:793 → 1047
      PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases

    3. NM_141840.1 → NP_650097.2  C-terminal Src kinase, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650097.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NP28, Q9VGK8, Q9VGK9
      Related
      FBpp0289773, FBtr0300546
      Conserved Domains (3) summary
      cd09937
      Location:433 → 530
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      smart00221
      Location:553 → 797
      STYKc; Protein kinase; unclassified specificity
      cd05039
      Location:546 → 800
      PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases

    4. NM_001275547.1 → NP_001262476.1  C-terminal Src kinase, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262476.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INJ8
      Conserved Domains (3) summary
      cd09937
      Location:680 → 777
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      smart00221
      Location:800 → 1044
      STYKc; Protein kinase; unclassified specificity
      cd05039
      Location:793 → 1047
      PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases

    5. NM_176461.1 → NP_788638.1  C-terminal Src kinase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788638.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NP28, Q7KSQ2
      Related
      FBpp0289006, FBtr0299728
      Conserved Domains (3) summary
      cd09937
      Location:351 → 448
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      smart00221
      Location:471 → 715
      STYKc; Protein kinase; unclassified specificity
      cd05039
      Location:464 → 718
      PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases

    6. NM_169415.2 → NP_731608.1  C-terminal Src kinase, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731608.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NP28, Q7KSQ2
      Related
      FBpp0289775, FBtr0300548
      Conserved Domains (3) summary
      cd09937
      Location:351 → 448
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      smart00221
      Location:471 → 715
      STYKc; Protein kinase; unclassified specificity
      cd05039
      Location:464 → 718
      PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases

    7. NM_169416.2 → NP_731609.1  C-terminal Src kinase, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731609.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NP28, Q7KSQ2
      Related
      FBpp0289776, FBtr0300549
      Conserved Domains (3) summary
      cd09937
      Location:351 → 448
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      smart00221
      Location:471 → 715
      STYKc; Protein kinase; unclassified specificity
      cd05039
      Location:464 → 718
      PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KSQ2 Q7KSQ2
    Q8INJ8 Q8INJ8
    Q9VGK8 Q9VGK8

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