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    Vps15 Vacuolar protein sorting 15 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41096, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Vps15provided by FlyBase
    Official Full Name
    Vacuolar protein sorting 15provided by FlyBase
    Primary source
    FLYBASE:FBgn0260935
    Locus tag
    Dmel_CG9746
    See related
    AllianceGenome:FB:FBgn0260935
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9746; Dmel\CG9746; dVps15; FBgn0260935; ird; ird1; Ird1; p150; vps15; VPS15
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including cellular response to amino acid starvation; larval midgut cell programmed cell death; and neuron remodeling. Part of phosphatidylinositol 3-kinase complex, class III, type I. Is expressed in adult head. Orthologous to human PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Vps15 in Genome Data Viewer
    Location:
    85D1-85D2; 3-48 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9240757..9245869, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5066479..5071591, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pumilio Neighboring gene long non-coding RNA:CR45196 Neighboring gene uncharacterized protein Neighboring gene D1 chromosomal protein Neighboring gene Sulfotransferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vps15 is required for stress induced and developmentally triggered autophagy and salivary gland protein secretion in Drosophila. Anding AL, et al. Cell Death Differ, 2015 Mar. PMID 25342466, Free PMC Article
    2. The PI 3-kinase regulator Vps15 is required for autophagic clearance of protein aggregates. Lindmo K, et al. Autophagy, 2008 May. PMID 18326940
    3. The multi-AT-hook chromosomal protein of Drosophila melanogaster, D1, is dispensable for viability. Weiler KS, et al. Genetics, 2009 May. PMID 19293138, Free PMC Article
    4. The localisation of PtdIns3P in Drosophila fat responds to nutrients but not insulin: a role for Class III but not Class II phosphoinositide 3-kinases. Powis KV, et al. Cell Signal, 2011 Jul. PMID 21385607
    5. Population genetic analysis of autophagy and phagocytosis genes in Drosophila melanogaster and D. simulans. Im JH, et al. PLoS One, 2018. PMID 30281656, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial structure maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment or maintenance of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in larval midgut cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in late endosome to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in late endosome to vacuole transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macroautophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macroautophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pexophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of antimicrobial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus-vacuole junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class III, type I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class III, type I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class III, type II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar protein sorting 15
    Names
    CG9746-PA
    CG9746-PB
    CG9746-PC
    Vps15-PA
    Vps15-PB
    Vps15-PC
    immune response deficient 1
    immune response-deficient 1
    NP_001163565.1
    NP_001262405.1
    NP_649868.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9240757..9245869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141611.2 → NP_649868.1  vacuolar protein sorting 15, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649868.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHH2
      Related
      FBpp0081466
      Conserved Domains (6) summary
      smart00220
      Location:41 → 311
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG2319
      Location:958 → 1342
      WD40; WD40 repeat [General function prediction only]
      cd13980
      Location:27 → 325
      STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
      sd00044
      Location:483 → 508
      HEAT; HEAT repeat [structural motif]
      sd00039
      Location:1020 → 1063
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:953 → 1240
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001275476.1 → NP_001262405.1  vacuolar protein sorting 15, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262405.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGX5
      Conserved Domains (3) summary
      smart00220
      Location:41 → 311
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13980
      Location:27 → 325
      STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
      sd00044
      Location:483 → 508
      HEAT; HEAT repeat [structural motif]

    3. NM_001170094.2 → NP_001163565.1  vacuolar protein sorting 15, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163565.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIG3
      Conserved Domains (3) summary
      smart00220
      Location:41 → 311
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13980
      Location:27 → 325
      STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
      sd00044
      Location:483 → 508
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGX5 A0A0B4KGX5
    E1JIG3 E1JIG3
    Q961J4 Q961J4
    Q9VHH2 Q9VHH2

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