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    Ubc84D Ubiquitin conjugating enzyme 84D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40900, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Ubc84Dprovided by FlyBase
    Official Full Name
    Ubiquitin conjugating enzyme 84Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0017456
    Locus tag
    Dmel_CG12799
    See related
    AllianceGenome:FB:FBgn0017456
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12799; Dmel\CG12799; ubc; UbcD84
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to several human genes including UBE2L3 (ubiquitin conjugating enzyme E2 L3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Ubc84D in Genome Data Viewer
    Location:
    84D9-84D9; 3-48 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7518820..7519456, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3344542..3345178, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene alpha-Esterase-9 Neighboring gene Mitochondrial morphology and cristae structure 1 Neighboring gene alpha-Esterase-8 Neighboring gene alpha-Esterase-7 Neighboring gene pseudo Neighboring gene alpha-Esterase-6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Duplication and divergence of the genes of the alpha-esterase cluster of Drosophila melanogaster. Robin C, et al. J Mol Evol, 1996 Sep. PMID 8703090
    2. Reconstructing the diversification of alpha-esterases: comparing the gene clusters of Drosophila buzzatii and D. melanogaster. de Q Robin GC, et al. J Mol Evol, 2000 Aug. PMID 10948271
    3. The evolution of an alpha-esterase pseudogene inactivated in the Drosophila melanogaster lineage. Robin GC, et al. Mol Biol Evol, 2000 Apr. PMID 10742048
    4. UbcD4, an ortholog of E2-25K/Ube2K, is essential for activation of the immune deficiency pathway in Drosophila. Park ES, et al. Biochem Biophys Res Commun, 2016 Jan 22. PMID 26707646
    5. Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins. Jones D, et al. Genome Biol, 2002. PMID 11806825, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin conjugating enzyme 84D
    Names
    CG12799-PA
    Ubc84D-PA
    ubiquitin conjugating enzyme
    NP_524260.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7518820..7519456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079536.3 → NP_524260.1  ubiquitin conjugating enzyme 84D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524260.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C4XVG9, P52487, Q9VIB4
      UniProtKB/TrEMBL
      A0A1B2AJX4
      Related
      FBpp0081076
      Conserved Domains (2) summary
      smart00212
      Location:6 → 149
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
      COG5078
      Location:1 → 150
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52487.2 P52487

    Gene LinkOut

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