lab labial [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: labprovided by FlyBase
Official Full Name: labialprovided by FlyBase
Primary source: FLYBASE:FBgn0002522
Locus tag: Dmel_CG1264
See related: AllianceGenome:FB:FBgn0002522
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BG:DS00004.9; CG1264; Dm lab; Dmel\CG1264; Dmlab; DmLab; EfR9; F121; F24; F90; F90-2; l(3)01241; l(3)84Ac; Lab; LAB; lb
Summary: Enables cis-regulatory region sequence-specific DNA binding activity and protein heterodimerization activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in brain segmentation; head morphogenesis; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including dorsal closure embryo; germ layer; gut section; head segment; and midgut primordium. Human ortholog(s) of this gene implicated in Athabaskan brainstem dysgenesis syndrome and autistic disorder. Orthologous to several human genes including HOXA1 (homeobox A1) and HOXB1 (homeobox B1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (6661427..6678590, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (2487149..2504312, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Labial, Ultrabithorax, Antennapedia, Extradenticle and Homothorax are regulated in a signal transduction pathway in developing Drosophila brain
Title: Hox gene cross-regulatory interactions in the embryonic brain of Drosophila.
selects different DNA sequences in regulating downstream target genes
Title: Recognition of distinct target sites by a unique Labial/Extradenticle/Homothorax complex.
labial protein was expressed in adult labk3/labvd1 copper cells, but not in larvae
Title: Differential effects of a labial mutation on the development, structure, and function of stomach acid-secreting cells in Drosophila melanogaster larvae and adults.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in brain development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain segmentation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in cell fate determination	TAS Traceable Author Statement more info	PubMed
involved_in head morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midgut development	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info