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    INSR insulin receptor [ Bos taurus (domestic cattle) ]

    Gene ID: 408017, updated on 4-Oct-2024

    Summary

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    Official Symbol
    INSRprovided by VGNC
    Official Full Name
    insulin receptorprovided by VGNC
    Primary source
    VGNC:VGNC:30221
    See related
    BGD:BT11831; Ensembl:ENSBTAG00000012687
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    ir-A
    Orthologs
    human mouse all
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    Genomic context

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    See INSR in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (16054185..16200493, complement)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene RNA-binding protein S1, serine-rich domain-like Neighboring gene methyl-CpG binding domain protein 3-like 3 Neighboring gene uncharacterized LOC112447347 Neighboring gene Rho/Rac guanine nucleotide exchange factor 18 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene peroxisomal biogenesis factor 11 gamma

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insulin receptor gene expression in normal and diseased bovine liver. Liu GW, et al. J Comp Pathol, 2010 Nov. PMID 20627313
    2. Abundance of mRNA encoding for components of the somatotropic axis and insulin receptor in different layers of the jejunum and ileum of neonatal calves. Ontsouka EC, et al. J Anim Sci, 2004 Nov. PMID 15542464
    3. The insulin receptor is expressed and functional in cultured blood-brain barrier endothelial cells but does not mediate insulin entry from blood to brain. Hersom M, et al. Am J Physiol Endocrinol Metab, 2018 Oct 1. PMID 29584446
    4. Insulin and insulin-like growth factor-I receptors differentially mediate insulin-stimulated adhesion molecule production by endothelial cells. Li G, et al. Endocrinology, 2009 Aug. PMID 19423756, Free PMC Article
    5. Involvement of insulin and growth hormone (GH) during follicular development in the bovine ovary. Shimizu T, et al. Anim Reprod Sci, 2008 Jun. PMID 17507188

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These in vitro data indicate that peripheral insulin must reach the brain parenchyma through alternative pathways rather than crossing the blood-brain barrier via INSR mediated transcytosis.
      Title: The insulin receptor is expressed and functional in cultured blood-brain barrier endothelial cells but does not mediate insulin entry from blood to brain.
    2. The expression of IR mRNA in the liver of ketotic dairy cows was higher than in cows with fatty liver, but in both disease groups the expression was substantially lower than that in normal liver.
      Title: Insulin receptor gene expression in normal and diseased bovine liver.
    3. Data conclude that insulin and IGF-I receptors differentially mediate the production of adhesion molecules by ECs and monocyte adhesion onto the vascular endothelium in response to the hyperinsulinemic state.
      Title: Insulin and insulin-like growth factor-I receptors differentially mediate insulin-stimulated adhesion molecule production by endothelial cells.
    4. FSH, but not E2, stimulated the expression of IR and GHR genes during follicular development.
      Title: Involvement of insulin and growth hormone (GH) during follicular development in the bovine ovary.
    5. insulin receptor and phosphoinositide 3-kinase localize to detergent-resistant membrane rafts of rod photoreceptor outer segments
      Title: Localization of the insulin receptor and phosphoinositide 3-kinase in detergent-resistant membrane rafts of rod photoreceptor outer segments.
    6. studied by RT reverse-transcription PCR, whether there are differences in the abundance of mRNA coding for IGF-I, IGF-2, IGFBP-2, IGFBP-3, IGF-1R, IGF-2R, GHR, and InsR in compartmentalized layers of jejunum and ileum of 5-d-old calves fed colostrum
      Title: Abundance of mRNA encoding for components of the somatotropic axis and insulin receptor in different layers of the jejunum and ileum of neonatal calves.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables insulin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables insulin receptor substrate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol 3-kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of insulin receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insulin receptor
    XP_002688878.3
    XP_005208872.1
    XP_005208873.1
    XP_005208874.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      16054185..16200493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005208817.5 → XP_005208874.1  insulin receptor isoform X4

      Conserved Domains (6) summary
      cd05061
      Location:1003 → 1290
      PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
      cd00063
      Location:855 → 932
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00064
      Location:234 → 281
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:179 → 337
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:359 → 472
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:1010 → 1277
      Pkinase_Tyr; Protein tyrosine kinase

    2. XM_005208816.5 → XP_005208873.1  insulin receptor isoform X3

      See identical proteins and their annotated locations for XP_005208873.1

      UniProtKB/TrEMBL
      A0A3Q1MJG0
      Related
      ENSBTAP00000070910.2, ENSBTAT00000072886.2
      Conserved Domains (6) summary
      cd05061
      Location:1004 → 1291
      PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
      cd00063
      Location:855 → 932
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00064
      Location:234 → 281
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:179 → 337
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:359 → 472
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:1011 → 1278
      Pkinase_Tyr; Protein tyrosine kinase

    3. XM_005208815.5 → XP_005208872.1  insulin receptor isoform X2

      Conserved Domains (6) summary
      cd05061
      Location:1015 → 1302
      PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
      cd00063
      Location:867 → 944
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00064
      Location:234 → 281
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:179 → 337
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:359 → 472
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:1022 → 1289
      Pkinase_Tyr; Protein tyrosine kinase

    4. XM_002688832.7 → XP_002688878.3  insulin receptor isoform X1

      See identical proteins and their annotated locations for XP_002688878.3

      UniProtKB/TrEMBL
      F1MV64
      Related
      ENSBTAP00000016858.7, ENSBTAT00000016858.7
      Conserved Domains (6) summary
      cd05061
      Location:1016 → 1303
      PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
      cd00063
      Location:867 → 944
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00064
      Location:234 → 281
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:179 → 337
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:359 → 472
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:1023 → 1290
      Pkinase_Tyr; Protein tyrosine kinase
    Nucleotide Protein Strain
    Heading Accession and Version

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