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    GARS1 glycyl-tRNA synthetase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 408010, updated on 10-Oct-2024

    Summary

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    Official Symbol
    GARS1provided by VGNC
    Official Full Name
    glycyl-tRNA synthetase 1provided by VGNC
    Primary source
    VGNC:VGNC:29254
    See related
    BGD:BT29986; Ensembl:ENSBTAG00000018972
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    GARS
    Orthologs
    human mouse all
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    Genomic context

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    See GARS1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (65704795..65758336, complement)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene indolethylamine N-methyltransferase Neighboring gene corticotropin releasing hormone receptor 2 Neighboring gene uncharacterized LOC132345106 Neighboring gene gamma-glutamylcyclotransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Methionine stimulates GlyRS phosphorylation via the GPR87-CDC42/Rac1-MAP3K10 signaling pathway. Luo C, et al. Biochem Biophys Res Commun, 2020 Mar 19. PMID 31954518
    2. GlyRS is a new mediator of amino acid-induced milk synthesis in bovine mammary epithelial cells. Luo C, et al. J Cell Physiol, 2019 Mar. PMID 30171693
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Methionine stimulates GlyRS phosphorylation via the GPR87-CDC42/Rac1-MAP3K10 signaling pathway.
      Title: Methionine stimulates GlyRS phosphorylation via the GPR87-CDC42/Rac1-MAP3K10 signaling pathway.
    2. this study establishes that GlyRS mediates amino acid-induced activation of the mTOR pathway, thereby regulating milk protein and fat synthesis.
      Title: GlyRS is a new mediator of amino acid-induced milk synthesis in bovine mammary epithelial cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables glycine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial glycyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glycine--tRNA ligase
    Names
    glycyl-tran synthetase
    NP_001091035.1
    XP_059741414.1
    XP_059741416.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001097566.1 → NP_001091035.1  glycine--tRNA ligase

      See identical proteins and their annotated locations for NP_001091035.1

      Status: PROVISIONAL

      Source sequence(s)
      BC140482
      UniProtKB/TrEMBL
      A0AAA9TK53, A5D7A2
      Related
      ENSBTAP00000025254.5, ENSBTAT00000025254.6
      Conserved Domains (1) summary
      PLN02734
      Location:61 → 725
      PLN02734; glycyl-tRNA synthetase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      65704795..65758336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059885431.1 → XP_059741414.1  glycine--tRNA ligase isoform X1

      UniProtKB/TrEMBL
      A5D7A2

    2. XM_059885433.1 → XP_059741416.1  glycine--tRNA ligase isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials