EGR1 early growth response 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: EGR1provided by VGNC
Official Full Name: early growth response 1provided by VGNC
Primary source: VGNC:VGNC:52766
See related: BGD:BT24351; Ensembl:ENSBTAG00000010069
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	7	NC_037334.1 (49826725..49829568)

Chromosome 7 - NC_037334.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

During the differentiation of bovine skeletal muscle satellite cells, the transcriptional level of EGR1 gene is increased, and some EGR1 proteins are transferred into the nucleus.
Title: [Expression of EGR1 gene and location of EGR1 protein in differentiation of bovine skeletal muscle-derived satellite cells].
This is the first study to reveal that bta-miR-2361 as a novel host factor regulates Bovine herpesvirus 1 replication via directly targeting the EGR1 gene.
Title: Cellular microRNA bta-miR-2361 inhibits bovine herpesvirus 1 replication by directly targeting EGR1 gene.
EGR1 is a major upstream component of FGF signaling in theca cells and that it directs cell fate toward proliferation.
Title: Effects of fibroblast growth factors and the transcription factor, early growth response 1, on bovine theca cells.
Suggest that EGR1 is likely an upstream component of FGF signaling in granulosa cells.
Title: Regulation and action of early growth response 1 in bovine granulosa cells.
EGR1 can promote skeletal muscle satellite cell differentiation through positive regulation of MyoG gene expression.
Title: Transcription factor EGR1 promotes differentiation of bovine skeletal muscle satellite cells by regulating MyoG gene expression.
Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
Title: Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia.
The authors conclude that Egr-1 protein expression is very sensitive to upregulation by hypoxia in pulmonary artery adventitial fibroblasts and that it plays an important role in the autonomous growth phenotype induced by hypoxia in these cells.
Title: Egr-1 antisense oligonucleotides inhibit hypoxia-induced proliferation of pulmonary artery adventitial fibroblasts.
EGR-1's expression prior to ovulation and its stimulating effect on the expression of genes known to be involved in prostaglandin biosynthesis pathway, suggest its potential involvement in the regulation of preovulatory events in cattle.
Title: Characterization of bovine early growth response factor-1 and its gonadotropin-dependent regulation in ovarian follicles prior to ovulation.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: early growth response protein 1

Names: EGR-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045875.1 → NP_001039340.1 early growth response protein 1

See identical proteins and their annotated locations for NP_001039340.1

Status: PROVISIONAL

Source sequence(s)

AY924307

UniProtKB/Swiss-Prot

Q29W20

UniProtKB/TrEMBL

Q17QJ4

Related

ENSBTAP00000013284.5, ENSBTAT00000013284.7

Conserved Domains (6) summary

sd00017
Location:339 → 361

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:337 → 361

zf-C2H2; Zinc finger, C2H2 type

pfam05687
Location:436 → 502

BES1_N; BES1/BZR1 plant transcription factor, N-terminal

pfam11914
Location:444 → 527

DUF3432; Domain of unknown function (DUF3432)

pfam11928
Location:135 → 208

DUF3446; Domain of unknown function (DUF3446)

pfam13465
Location:380 → 405

zf-H2C2_2; Zinc-finger double domain