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    TJP2 tight junction protein 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 407101, updated on 10-Oct-2024

    Summary

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    Official Symbol
    TJP2provided by VGNC
    Official Full Name
    tight junction protein 2provided by VGNC
    Primary source
    VGNC:VGNC:35882
    See related
    BGD:BT27131; Ensembl:ENSBTAG00000011770
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    zo2
    Orthologs
    human mouse all
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    Genomic context

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    See TJP2 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (45314360..45413180)

    Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 beta Neighboring gene uncharacterized LOC101902390 Neighboring gene frataxin Neighboring gene endosomal transmembrane epsin interactor 1 Neighboring gene uncharacterized LOC132345956 Neighboring gene amyloid beta precursor protein binding family A member 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC159949

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell junction organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in establishment of endothelial intestinal barrier IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of blood-brain barrier permeability IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein localization to cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tight junction protein ZO-2
    Names
    tight junction protein 2 (zona occludens 2)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102482.1 → NP_001095952.1  tight junction protein ZO-2

      See identical proteins and their annotated locations for NP_001095952.1

      Status: PROVISIONAL

      Source sequence(s)
      BC149801
      UniProtKB/TrEMBL
      A6QQF3
      Conserved Domains (3) summary
      smart00072
      Location:478 → 657
      GuKc; Guanylate kinase homologues
      smart00228
      Location:265 → 346
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:9 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      45314360..45413180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010807869.4 → XP_010806171.2  tight junction protein ZO-2 isoform X7

      UniProtKB/TrEMBL
      A0A3Q1MPV5
      Related
      ENSBTAP00000073560.2, ENSBTAT00000082489.2
      Conserved Domains (5) summary
      cd12027
      Location:565 → 627
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:661 → 840
      GuKc; Guanylate kinase homologues
      smart00228
      Location:265 → 346
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:9 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl25887
      Location:153 → 278
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    2. XM_005210008.3 → XP_005210065.2  tight junction protein ZO-2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LY05, A0A3Q1MPV5
      Related
      ENSBTAP00000062148.2, ENSBTAT00000078877.2
      Conserved Domains (5) summary
      cd12027
      Location:588 → 650
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:684 → 863
      GuKc; Guanylate kinase homologues
      smart00228
      Location:288 → 369
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:32 → 117
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl25887
      Location:176 → 301
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    3. XM_059888970.1 → XP_059744953.1  tight junction protein ZO-2 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1NJS7
      Related
      ENSBTAP00000072462.2, ENSBTAT00000075921.2

    4. XM_024995497.2 → XP_024851265.1  tight junction protein ZO-2 isoform X6

      UniProtKB/TrEMBL
      A0A3Q1MJ12
      Conserved Domains (5) summary
      cd12027
      Location:588 → 650
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:684 → 863
      GuKc; Guanylate kinase homologues
      smart00228
      Location:288 → 369
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:32 → 117
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam17069
      Location:148 → 300
      RSRP; Arginine/Serine-Rich protein 1

    5. XM_024995496.2 → XP_024851264.1  tight junction protein ZO-2 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1MJ12
      Conserved Domains (5) summary
      cd12027
      Location:592 → 654
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:688 → 867
      GuKc; Guanylate kinase homologues
      smart00228
      Location:292 → 373
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:36 → 121
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam17069
      Location:152 → 304
      RSRP; Arginine/Serine-Rich protein 1

    6. XM_005210007.5 → XP_005210064.2  tight junction protein ZO-2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MEH9, A0A3Q1MPV5
      Related
      ENSBTAP00000072570.1, ENSBTAT00000069935.2
      Conserved Domains (5) summary
      cd12027
      Location:592 → 654
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:688 → 867
      GuKc; Guanylate kinase homologues
      smart00228
      Location:292 → 373
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:36 → 121
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl25887
      Location:180 → 305
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    7. XM_024995494.2 → XP_024851262.1  tight junction protein ZO-2 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1MPV5
      Conserved Domains (5) summary
      cd12027
      Location:592 → 654
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:688 → 867
      GuKc; Guanylate kinase homologues
      smart00228
      Location:292 → 373
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:36 → 121
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam17069
      Location:152 → 304
      RSRP; Arginine/Serine-Rich protein 1
    Nucleotide Protein Strain
    Heading Accession and Version

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