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    CD4 CD4 molecule [ Bos taurus (domestic cattle) ]

    Gene ID: 407098, updated on 4-Oct-2024

    Summary

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    Official Symbol
    CD4provided by VGNC
    Official Full Name
    CD4 moleculeprovided by VGNC
    Primary source
    VGNC:VGNC:27032
    See related
    Ensembl:ENSBTAG00000003255
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CD4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (103631358..103654777, complement)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene prolyl 3-hydroxylase 3 Neighboring gene G protein-coupled receptor 162 Neighboring gene lymphocyte activating 3 Neighboring gene parathymosin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new polymorphic epitope of bovine CD4 antigen evidenced by flow cytometry. Grandoni F, et al. Vet Immunol Immunopathol, 2020 Jan. PMID 31706083
    2. Association of CD4 SNPs with fat percentage of Holstein cattle. Usman T, et al. Genet Mol Res, 2016 Sep 16. PMID 27706731
    3. Aberrant promoter methylation of the CD4 gene in peripheral blood cells of mastitic dairy cows. Wang XS, et al. Genet Mol Res, 2013 Dec 4. PMID 24338418
    4. Subpopulations of bovine WC1(+) gammadelta T cells rather than CD4(+)CD25(high) Foxp3(+) T cells act as immune regulatory cells ex vivo. Hoek A, et al. Vet Res, 2009 Jan-Feb. PMID 18928784, Free PMC Article
    5. Association of bovine CD4 and STAT5b single nucleotide polymorphisms with somatic cell scores and milk production traits in Chinese Holsteins. He Y, et al. J Dairy Res, 2011 May. PMID 21435309

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A new polymorphic epitope of bovine CD4 antigen evidenced by flow cytometry.
      Title: A new polymorphic epitope of bovine CD4 antigen evidenced by flow cytometry.
    2. These results suggest that CD4 plays a role in production traits as well as in immune function. The identified SNPs could be used as genetic markers for selection of dairy cows with improved fat percentage. We propose further studies of these SNPs in a larger population as well as further investigations of the function of this gene.
      Title: Association of CD4 SNPs with fat percentage of Holstein cattle.
    3. These results suggested that the SNPs in CD4 and STAT5b may be potential genetic markers for SCS and milk/protein yields selecting and warrant further functional research.
      Title: Association of bovine CD4 and STAT5b single nucleotide polymorphisms with somatic cell scores and milk production traits in Chinese Holsteins.
    4. The DNA methylation level of the CD4 gene was strongly influenced by mastitis in Chinese Holstein cattle.
      Title: Aberrant promoter methylation of the CD4 gene in peripheral blood cells of mastitic dairy cows.
    5. These findings revealed that despite the existence of a distinct bovine CD4(+)CD25(high) T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in this cell population
      Title: Subpopulations of bovine WC1(+) gammadelta T cells rather than CD4(+)CD25(high) Foxp3(+) T cells act as immune regulatory cells ex vivo.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC165891

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables MHC class II protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables coreceptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in interleukin-15-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    T-cell surface glycoprotein CD4
    Names
    CD4 antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001103225.1 → NP_001096695.1  T-cell surface glycoprotein CD4 precursor

      See identical proteins and their annotated locations for NP_001096695.1

      Status: PROVISIONAL

      Source sequence(s)
      BC151321
      UniProtKB/TrEMBL
      A7YY52, F6Q6F6
      Related
      ENSBTAP00000004219.6, ENSBTAT00000004219.6
      Conserved Domains (2) summary
      pfam09191
      Location:208 → 313
      CD4-extracel; CD4, extracellular
      cl11960
      Location:28 → 121
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      103631358..103654777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024991416.2 → XP_024847184.1  T-cell surface glycoprotein CD4 isoform X1

      UniProtKB/TrEMBL
      I0J0K1
      Related
      ENSBTAP00000065859.2, ENSBTAT00000080175.2
      Conserved Domains (3) summary
      pfam12104
      Location:423 → 450
      Tcell_CD4_C; T cell CD4 receptor C terminal region
      pfam09191
      Location:208 → 313
      CD4-extracel; CD4, extracellular
      cl11960
      Location:28 → 121
      Ig; Immunoglobulin domain

    2. XM_024991417.2 → XP_024847185.1  T-cell surface glycoprotein CD4 isoform X1

      UniProtKB/TrEMBL
      I0J0K1
      Conserved Domains (3) summary
      pfam12104
      Location:423 → 450
      Tcell_CD4_C; T cell CD4 receptor C terminal region
      pfam09191
      Location:208 → 313
      CD4-extracel; CD4, extracellular
      cl11960
      Location:28 → 121
      Ig; Immunoglobulin domain

    3. XM_024991418.2 → XP_024847186.1  T-cell surface glycoprotein CD4 isoform X2

      UniProtKB/TrEMBL
      A7YY52, F6Q6F6
      Conserved Domains (2) summary
      pfam09191
      Location:208 → 313
      CD4-extracel; CD4, extracellular
      cl11960
      Location:28 → 121
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials