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    Hcs Holocarboxylase synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40659, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Hcsprovided by FlyBase
    Official Full Name
    Holocarboxylase synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037332
    Locus tag
    Dmel_CG14670
    See related
    AllianceGenome:FB:FBgn0037332
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14670; Dmel\CG14670; HCS; HSC; NEST:bs27h05
    Summary
    Involved in histone biotinylation; peptidyl-lysine biotinylation; and response to heat. Located in polytene chromosome. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in holocarboxylase synthetase deficiency. Orthologous to human HLCS (holocarboxylase synthetase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See Hcs in Genome Data Viewer
    Location:
    83A5-83A5; 3-47.5 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5474899..5485393)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1300621..1311115)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Snf5-related 1 Neighboring gene uncharacterized protein Neighboring gene Histone deacetylase 3 Neighboring gene kinase suppressor of ras Neighboring gene uncharacterized protein Neighboring gene sodium potassium chloride cotransporter

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Trafficking and chromatin dynamics of holocarboxylase synthetase during development of Drosophila melanogaster. Reyes-Carmona S, et al. Mol Genet Metab, 2011 Jul. PMID 21463962
    2. Drosophila melanogaster holocarboxylase synthetase is a chromosomal protein required for normal histone biotinylation, gene transcription patterns, lifespan, and heat tolerance. Camporeale G, et al. J Nutr, 2006 Nov. PMID 17056793, Free PMC Article
    3. Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model. Lohr KM, et al. Proc Natl Acad Sci U S A, 2020 Dec 29. PMID 33318181, Free PMC Article
    4. Susceptibility to heat stress and aberrant gene expression patterns in holocarboxylase synthetase-deficient Drosophila melanogaster are caused by decreased biotinylation of histones, not of carboxylases. Camporeale G, et al. J Nutr, 2007 Apr. PMID 17374649, Free PMC Article
    5. Specific SR protein-dependent splicing substrates identified through genomic SELEX. Kim S, et al. Nucleic Acids Res, 2003 Apr 1. PMID 12655012, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HCS may have a role in the repression of gene expression through a mechanism involving its trafficking to the nucleus and interaction with heterochromatic sites coincident with H3K9met3.
      Title: Trafficking and chromatin dynamics of holocarboxylase synthetase during development of Drosophila melanogaster.
    2. Gene expression patterns and phenotypes in holocarboxylase synthetase-deficient flies in previous studies are caused by decreased biotinylation of histones, not 3-methylcrotonyl-CoA carboxylase.
      Title: Susceptibility to heat stress and aberrant gene expression patterns in holocarboxylase synthetase-deficient Drosophila melanogaster are caused by decreased biotinylation of histones, not of carboxylases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables biotin--[biotin carboxyl-carrier protein] ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables biotin--[biotin carboxyl-carrier protein] ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables biotin--[biotin carboxyl-carrier protein] ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    holocarboxylase synthetase
    Names
    CG14670-PA
    CG14670-PB
    CG14670-PC
    CG14670-PD
    Hcs-PA
    Hcs-PB
    Hcs-PC
    Hcs-PD
    NP_001262284.1
    NP_001287175.1
    NP_001287176.1
    NP_649542.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5474899..5485393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300246.1 → NP_001287175.1  holocarboxylase synthetase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287175.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGM5
      Conserved Domains (5) summary
      COG0340
      Location:812 → 1037
      BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
      pfam02237
      Location:988 → 1037
      BPL_C; Biotin protein ligase C terminal domain
      pfam07382
      Location:293 → 437
      HC2; Histone H1-like nucleoprotein HC2
      cl00020
      Location:456 → 509
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
      cl14057
      Location:793 → 921
      BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family

    2. NM_141285.2 → NP_649542.1  holocarboxylase synthetase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649542.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNC3
      Related
      FBpp0078332
      Conserved Domains (5) summary
      COG0340
      Location:806 → 1031
      BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
      pfam02237
      Location:982 → 1031
      BPL_C; Biotin protein ligase C terminal domain
      pfam07382
      Location:293 → 437
      HC2; Histone H1-like nucleoprotein HC2
      cl00020
      Location:456 → 509
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
      cl14057
      Location:787 → 915
      BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family

    3. NM_001300247.1 → NP_001287176.1  holocarboxylase synthetase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287176.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGS6
      Conserved Domains (5) summary
      COG0340
      Location:764 → 989
      BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
      pfam02237
      Location:940 → 989
      BPL_C; Biotin protein ligase C terminal domain
      pfam07382
      Location:245 → 389
      HC2; Histone H1-like nucleoprotein HC2
      cl00020
      Location:408 → 461
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
      cl14057
      Location:745 → 873
      BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family

    4. NM_001275355.1 → NP_001262284.1  holocarboxylase synthetase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262284.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF92
      Conserved Domains (5) summary
      COG0340
      Location:758 → 983
      BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
      pfam02237
      Location:934 → 983
      BPL_C; Biotin protein ligase C terminal domain
      pfam07382
      Location:245 → 389
      HC2; Histone H1-like nucleoprotein HC2
      cl00020
      Location:408 → 461
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
      cl14057
      Location:739 → 867
      BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KF92 A0A0B4KF92
    A0A0B4LGM5 A0A0B4LGM5
    A0A0B4LGS6 A0A0B4LGS6
    Q9VNC3 Q9VNC3

    Gene LinkOut

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