sp9 sp9 transcription factor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sp9provided by ZNC
Official Full Name: sp9 transcription factorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2313
See related: Ensembl:ENSDARG00000099374 AllianceGenome:ZFIN:ZDB-GENE-040426-2313
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:85876
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic limb morphogenesis. Acts upstream of or within embryonic pectoral fin morphogenesis and positive regulation of fibroblast growth factor receptor signaling pathway. Predicted to be located in nucleus. Is expressed in several structures, including median fin fold; neural tube; pectoral fin bud; presumptive median fin fold; and tail bud. Orthologous to human SP9 (Sp9 transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (2591965..2594482, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (2585945..2588467, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sp8 and Sp9, via Fgf8, are involved in mediating the actions of Fgf10 and Wnt/beta-catenin signaling during vertebrate limb outgrowth.
Title: Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in embryonic limb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic pectoral fin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor Sp9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212960.2 → NP_998125.2 transcription factor Sp9

See identical proteins and their annotated locations for NP_998125.2

Status: PROVISIONAL

Source sequence(s)

AY591905

UniProtKB/Swiss-Prot

Q6NW96

Related

ENSDARP00000145264.1, ENSDART00000188306.1

Conserved Domains (3) summary

sd00017
Location:321 → 340

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:376 → 398

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:362 → 385

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007120.7 Reference GRCz11 Primary Assembly

Range

2591965..2594482 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005167414.5 → XP_005167471.1 transcription factor Sp9 isoform X1

See identical proteins and their annotated locations for XP_005167471.1

UniProtKB/Swiss-Prot

Q64HY6, Q6NW96

Related

ENSDARP00000141658.1, ENSDART00000164276.2

Conserved Domains (3) summary

sd00017
Location:313 → 332

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:368 → 390

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:354 → 377

zf-H2C2_2; Zinc-finger double domain