slc13a3 solute carrier family 13 member 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc13a3provided by ZNC
Official Full Name: solute carrier family 13 member 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2486
See related: Ensembl:ENSDARG00000069478 AllianceGenome:ZFIN:ZDB-GENE-040426-2486
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77173
Summary: Predicted to enable citrate transmembrane transporter activity; sodium:dicarboxylate symporter activity; and succinate transmembrane transporter activity. Predicted to be involved in anion transmembrane transport and citrate transport. Predicted to act upstream of or within sodium ion transport and transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including digestive system; hatching gland; head; kidney; and periocular mesenchyme. Orthologous to human SLC13A3 (solute carrier family 13 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (28667236..28694299)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (28658004..28685067)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables citrate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:dicarboxylate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in citrate transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in succinate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: solute carrier family 13 member 3

Names: solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212902.1 → NP_998067.1 solute carrier family 13 member 3

See identical proteins and their annotated locations for NP_998067.1

Status: PROVISIONAL

Source sequence(s)

BC067370

UniProtKB/TrEMBL

A0A8N7V0C9, Q6NWY4

Related

ENSDARP00000091933.2, ENSDART00000101159.4

Conserved Domains (2) summary

COG0471
Location:40 → 560

CitT; Di- and tricarboxylate transporter [Carbohydrate transport and metabolism]

cd01115
Location:41 → 560

SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...