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    chrnd cholinergic receptor, nicotinic, delta (muscle) [ Danio rerio (zebrafish) ]

    Gene ID: 404273, updated on 18-Sep-2024

    Summary

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    Official Symbol
    chrndprovided by ZNC
    Official Full Name
    cholinergic receptor, nicotinic, delta (muscle)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6665
    See related
    Ensembl:ENSDARG00000019342 AllianceGenome:ZFIN:ZDB-GENE-030131-6665
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fa01e01; zgc:110469
    Summary
    Enables acetylcholine-gated cation-selective channel activity. Acts upstream of or within myofibril assembly. Located in plasma membrane. Is expressed in musculature system and somite. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 3A; congenital myasthenic syndrome 3B; and congenital myasthenic syndrome 3C. Orthologous to human CHRND (cholinergic receptor nicotinic delta subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See chrnd in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (25683024..25691020, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (25538073..25546069, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene small muscle protein X-linked Neighboring gene connector enhancer of kinase suppressor of Ras 2a Neighboring gene kelch like family member 34 Neighboring gene calcium/calmodulin-dependent protein kinase II inhibitor 2 Neighboring gene uncharacterized LOC137489248

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expressing acetylcholine receptors after innervation suppresses spontaneous vesicle release and causes muscle fatigue. Mott M, et al. Sci Rep, 2017 May 10. PMID 28490756, Free PMC Article
    2. Anaesthetic tricaine acts preferentially on neural voltage-gated sodium channels and fails to block directly evoked muscle contraction. Attili S, et al. PLoS One, 2014. PMID 25090007, Free PMC Article
    3. Development of skeletal muscle sodium and potassium currents in zebrafish sofa potato mutants. Coutts CA, et al. Dev Neurosci, 2009. PMID 19270440
    4. Acetylcholine receptors direct rapsyn clusters to the neuromuscular synapse in zebrafish. Ono F, et al. J Neurosci, 2004 Jun 16. PMID 15201319, Free PMC Article
    5. Uncoupling nicotine mediated motoneuron axonal pathfinding errors and muscle degeneration in zebrafish. Welsh L, et al. Toxicol Appl Pharmacol, 2009 May 15. PMID 18694773, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutation in the delta-subunit of nAChR suppresses the muscle defects caused by lack of dystrophin.
      Title: Mutation in the delta-subunit of the nAChR suppresses the muscle defects caused by lack of Dystrophin.
    2. sop(-/-) mutants are able to support normal potassium current development during early stages of development but at day 6 the potassium current density is significantly smaller than that in wild-type siblings. sodium current density is unaffected
      Title: Development of skeletal muscle sodium and potassium currents in zebrafish sofa potato mutants.
    3. direct involvement of the AChR molecule in restricting receptor-rapsyn clusters to the synapse
      Title: Acetylcholine receptors direct rapsyn clusters to the neuromuscular synapse in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC110469

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acetylcholine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylcholine-gated monoatomic cation-selective channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylcholine-gated monoatomic cation-selective channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetylcholine-gated monoatomic cation-selective channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chemical synaptic transmission, postsynaptic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membrane depolarization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic cation transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of acetylcholine-gated channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of acetylcholine-gated channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    acetylcholine receptor subunit delta
    Names
    acetylcholine receptor delta subunit
    cholinergic receptor, nicotinic, delta polypeptide
    sofa potato
    sop

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207064.2 → NP_996947.1  acetylcholine receptor subunit delta precursor

      See identical proteins and their annotated locations for NP_996947.1

      Status: VALIDATED

      Source sequence(s)
      CU929293
      UniProtKB/TrEMBL
      A0A8M1PF39, Q75XT1
      Related
      ENSDARP00000016537.7, ENSDART00000015391.8
      Conserved Domains (3) summary
      TIGR00860
      Location:6 → 493
      LIC; Cation transporter family protein
      pfam02931
      Location:25 → 245
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:252 → 490
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      25683024..25691020 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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