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    ALOX5 arachidonate 5-lipoxygenase [ Bos taurus (domestic cattle) ]

    Gene ID: 404074, updated on 4-Oct-2024

    Summary

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    Official Symbol
    ALOX5provided by VGNC
    Official Full Name
    arachidonate 5-lipoxygenaseprovided by VGNC
    Primary source
    VGNC:VGNC:25844
    See related
    BGD:BT12481; Ensembl:ENSBTAG00000020319
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Annotation information
    Annotation category: suggests misassembly
    Orthologs
    human mouse all
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    Genomic context

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    See ALOX5 in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 28 NC_037355.1 (44346284..44392527, complement)

    Chromosome 28 - NC_037355.1Genomic Context describing neighboring genes Neighboring gene zinc finger AN1-type containing 4 Neighboring gene membrane associated ring-CH-type finger 8 Neighboring gene uncharacterized LOC112444772 Neighboring gene olfactory receptor family 13 subfamily A member 1 Neighboring gene olfactory receptor family 6 subfamily D member 16

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables arachidonate 5-lipoxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in linoleic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipid oxidation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polyunsaturated fatty acid 5-lipoxygenase
    NP_001179721.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192792.2 → NP_001179721.1  polyunsaturated fatty acid 5-lipoxygenase

      See identical proteins and their annotated locations for NP_001179721.1

      Status: VALIDATED

      Source sequence(s)
      BC151634, EH163865, NKLS02000028
      UniProtKB/TrEMBL
      A0A3Q1ME87, F1MQ78
      Related
      ENSBTAP00000027080.5, ENSBTAT00000027080.7
      Conserved Domains (2) summary
      cd01753
      Location:2 → 115
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:227 → 665
      Lipoxygenase; Lipoxygenase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037355.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      44346284..44392527 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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