TUBA1A tubulin, alpha 1a [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: TUBA1A
Gene description: tubulin, alpha 1a
See related: BGD:BT12059; Ensembl:ENSBTAG00000001489
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
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Genomic context

Location:: chromosome: 5

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	5	NC_037332.1 (30656035..30660487)

Chromosome 5 - NC_037332.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lys40 of alpha-tubulin acetylation directly weakens inter-protofilament interactions.
Title: Tubulin acetylation protects long-lived microtubules against mechanical ageing.
the role of the human TBCE and TBCB chaperones in alpha-tubulin-beta-tubulin dissociation, was investigated.
Title: The structure of the complex between α-tubulin, TBCE and TBCB reveals a tubulin dimer dissociation mechanism.
Lysine 40 acetylation of alpha-tubulin does not result in significant changes in kinesin-1's landing rate or motility parameters.
Title: Effects of α-tubulin K40 acetylation and detyrosination on kinesin-1 motility in a purified system.
Data suggest presence of unstructured C-terminal tubulin tail in Vdac1 pore (voltage-dependent anion channel 1) decreases pore's conductance and switches pore's selectivity from anionic to cationic rendering ATP transport virtually impossible.
Title: ATP transport through VDAC and the VDAC-tubulin complex probed by equilibrium and nonequilibrium MD simulations.
TTL has specifically evolved to recognize and modify tubulin.
Title: Structural basis of tubulin tyrosination by tubulin tyrosine ligase.
VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin.
Title: Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D22S1042 (e-PCR)
- UniSTS:67652

RH48063 (e-PCR)
- UniSTS:67653

D5Arb10 (e-PCR)
- UniSTS:240478

RH78682 (e-PCR)
- UniSTS:80224

Tuba1a (e-PCR), detects polymorphism
- UniSTS:532393

PMC154451P2 (e-PCR)
- UniSTS:271312

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in mitotic cell cycle	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tubulin alpha-1B chain

Names: alpha-tubulin ubiquitous; tubulin K-alpha-1; tubulin alpha-ubiquitous chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.