traf4b tnf receptor-associated factor 4b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: traf4bprovided by ZNC
Official Full Name: tnf receptor-associated factor 4bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040305-2
See related: Ensembl:ENSDARG00000038964 AllianceGenome:ZFIN:ZDB-GENE-040305-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: traf4
Summary: Predicted to enable signaling adaptor activity. Predicted to be involved in cell surface receptor signaling pathway and regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within several processes, including activation of NF-kappaB-inducing kinase activity; positive regulation of JNK cascade; and protein ubiquitination. Predicted to be active in cytoplasm. Orthologous to human TRAF4 (TNF receptor associated factor 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (39005909..39024739, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (38960957..38979787, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cloning of two zebrafish orthologs of the human traf4, traf4a and traf4b; during embryogenesis, traf4b expression is present in a weak ubiquitous manner
Title: Spatial and temporal distribution of the traf4 genes during zebrafish development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within activation of NF-kappaB-inducing kinase activity	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
NOT involved_in tumor necrosis factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of plasma membrane signaling receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: TNF receptor-associated factor 4b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212817.2 → NP_997982.1 TNF receptor-associated factor 4b

See identical proteins and their annotated locations for NP_997982.1

Status: VALIDATED

Source sequence(s)

CU463284

UniProtKB/TrEMBL

B2GT41, F6NVL3, Q7T1K1

Related

ENSDARP00000056877.3, ENSDART00000056878.4

Conserved Domains (3) summary

cd00162
Location:18 → 55

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd03781
Location:308 → 471

MATH_TRAF4; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF4 subfamily, TRAF domain, C-terminal MATH subdomain; composed of proteins with similarity to human TRAF4, including the Drosophila protein DTRAF1. TRAF molecules serve as adapter ...

pfam02176
Location:210 → 269

zf-TRAF; TRAF-type zinc finger