U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    RAB7A RAB7A, member RAS oncogene family [ Canis lupus familiaris (dog) ]

    Gene ID: 404007, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    RAB7Aprovided by VGNC
    Official Full Name
    RAB7A, member RAS oncogene familyprovided by VGNC
    Primary source
    VGNC:VGNC:45293
    See related
    Ensembl:ENSCAFG00845019242
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    RAB7
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See RAB7A in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (2724992..2797106)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (2792411..2812258)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (2783313..2803191)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (2496060..2515882)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (2822274..2842051)

    Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene ribophorin I Neighboring gene uncharacterized LOC111091224 Neighboring gene small nuclear ribonucleoprotein G-like Neighboring gene uncharacterized LOC111091356 Neighboring gene H1.10 linker histone

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Rab7 activation by growth factor withdrawal contributes to the induction of apoptosis. Romero Rosales K, et al. Mol Biol Cell, 2009 Jun. PMID 19386765, Free PMC Article
    2. Rab 7: an important regulator of late endocytic membrane traffic. Feng Y, et al. J Cell Biol, 1995 Dec. PMID 8522602, Free PMC Article
    3. Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments. Chavrier P, et al. Cell, 1990 Jul 27. PMID 2115402
    4. Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth. Raiborg C, et al. Nature, 2015 Apr 9. PMID 25855459
    5. rab7 activity affects epidermal growth factor:epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosome. Ceresa BP, et al. J Biol Chem, 2006 Jan 13. PMID 16282324

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rab7 activation by growth factor withdrawal contributes to the induction of apoptosis.
      Title: Rab7 activation by growth factor withdrawal contributes to the induction of apoptosis.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endosome to lysosome transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phagosome-lysosome fusion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in late endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in phagocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    ras-related protein Rab-7a
    Names
    GTP-binding protein (rab7)
    RAB7, member RAS oncogene family
    NP_001003316.1
    XP_038282303.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003316.1 → NP_001003316.1  ras-related protein Rab-7a

      See identical proteins and their annotated locations for NP_001003316.1

      Status: PROVISIONAL

      Source sequence(s)
      M35522
      UniProtKB/Swiss-Prot
      P18067
      UniProtKB/TrEMBL
      A0A8C0QVB9, A0A8I3P691, A0A8P0TM43
      Conserved Domains (1) summary
      cd01862
      Location:9 → 179
      Rab7; Rab GTPase family 7 (Rab7)

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051824.1 Reference ROS_Cfam_1.0

      Range
      2724992..2797106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038426375.1 → XP_038282303.1  ras-related protein Rab-7a isoform X1

      UniProtKB/Swiss-Prot
      P18067
      UniProtKB/TrEMBL
      A0A8C0QVB9, A0A8I3P691, A0A8P0TM43
      Related
      ENSCAFP00845026809.1, ENSCAFT00845034249.1
      Conserved Domains (1) summary
      cd01862
      Location:9 → 179
      Rab7; Rab GTPase family 7 (Rab7)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049280.1 Alternate UMICH_Zoey_3.1

      Range
      2496060..2515882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

      Range
      2822274..2842051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

      Range
      2783313..2803191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      2792411..2812258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18067.1 GenPept UniProtKB/Swiss-Prot:P18067

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.