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    IL18 interleukin 18 [ Canis lupus familiaris (dog) ]

    Gene ID: 403796, updated on 17-Aug-2024

    Summary

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    Official Symbol
    IL18provided by VGNC
    Official Full Name
    interleukin 18provided by VGNC
    Primary source
    VGNC:VGNC:41951
    See related
    Ensembl:ENSCAFG00845001557
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    IGIF
    Orthologs
    human mouse all
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    Genomic context

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    See IL18 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (20994967..21017974)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (20907590..20917853)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (21018633..21028888)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (21069981..21080260)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (20970245..20980530)

    Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene 6-pyruvoyltetrahydropterin synthase Neighboring gene beta-carotene oxygenase 2 Neighboring gene testis expressed 12 Neighboring gene succinate dehydrogenase complex subunit D Neighboring gene translocase of inner mitochondrial membrane 8 homolog B Neighboring gene NKAP domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Canine interleukin-18 induces apoptosis and enhances Fas ligand mRNA expression in a canine carcinoma cell line. Okano F, et al. Anticancer Res, 2000 Sep-Oct. PMID 11131641
    2. Cloning, sequencing, and characterization of dog interleukin-18. Argyle DJ, et al. Immunogenetics, 1999 Jun. PMID 10380699
    3. Cloning of cDNA for canine interleukin-18 and canine interleukin-1beta converting enzyme and expression of canine interleukin-18. Okano F, et al. J Interferon Cytokine Res, 1999 Jan. PMID 10048765
    4. Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production. Micallef MJ, et al. Eur J Immunol, 1996 Jul. PMID 8766574
    5. Semi-quantitative analysis of multiple cytokines in canine peripheral blood mononuclear cells by [correction of zby] a single tube RT-PCR. Chamizo C, et al. Vet Immunol Immunopathol, 2001 Dec. PMID 11730929

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interleukin-18
    Names
    IFN-gamma-inducing factor
    IL-1 gamma
    IL-18
    interferon gamma-inducing factor
    interleukin 18 (interferon-gamma-inducing factor)
    interleukin-1 gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003169.1 → NP_001003169.1  interleukin-18 precursor

      See identical proteins and their annotated locations for NP_001003169.1

      Status: PROVISIONAL

      Source sequence(s)
      Y11133
      UniProtKB/Swiss-Prot
      Q9XSR0
      UniProtKB/TrEMBL
      A0A8C0NFQ6, A0A8I3MED9
      Conserved Domains (1) summary
      cl00094
      Location:78 → 179
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051809.1 Reference ROS_Cfam_1.0

      Range
      20994967..21017974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038664074.1 → XP_038520002.1  interleukin-18 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NFQ6, A0A8I3MED9, A0A8I3RRK2, A0A8P0NPX4
      Related
      ENSCAFP00845002124.1, ENSCAFT00845002682.1
      Conserved Domains (1) summary
      cl00094
      Location:85 → 197
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

    2. XM_038664075.1 → XP_038520003.1  interleukin-18 isoform X2

      UniProtKB/TrEMBL
      A0A8C0N696, A0A8C0NFQ6, A0A8I3ME31, A0A8I3MED9
      Related
      ENSCAFP00845002139.1, ENSCAFT00845002702.1
      Conserved Domains (1) summary
      cl00094
      Location:73 → 185
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049265.1 Alternate UMICH_Zoey_3.1

      Range
      21069981..21080260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

      Range
      20970245..20980530
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

      Range
      21018633..21028888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      20907590..20917853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XSR0.1 GenPept UniProtKB/Swiss-Prot:Q9XSR0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials