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    HTR1B 5-hydroxytryptamine receptor 1B [ Canis lupus familiaris (dog) ]

    Gene ID: 403741, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HTR1Bprovided by VGNC
    Official Full Name
    5-hydroxytryptamine receptor 1Bprovided by VGNC
    Primary source
    VGNC:VGNC:110597
    See related
    Ensembl:ENSCAFG00845008653
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See HTR1B in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (39430205..39431374, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (38541798..38542967, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (38869413..38870583, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (38755029..38756198, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (38739892..38741061, complement)

    Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119874277 Neighboring gene nucleolar protein of 40 kDa-like Neighboring gene U6 spliceosomal RNA Neighboring gene ATPase GET3-like Neighboring gene meiotic double-stranded break formation protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of the canine serotonin receptor 1B gene (htr1B). van den Berg L, et al. Gene, 2004 Feb 4. PMID 14729271
    2. Evidence for 5-HT1D beta but not 5-HT1D alpha receptor subtype expression in canine large coronary arteries and saphenous vein. Sgard F, et al. Cardiovasc Res, 1996 May. PMID 8763409
    3. A marker set for construction of a genetic map of the silver fox (Vulpes vulpes). Kukekova AV, et al. J Hered, 2004 May-Jun. PMID 15220384
    4. Evaluation of the serotonergic genes htr1A, htr1B, htr2A, and slc6A4 in aggressive behavior of golden retriever dogs. van den Berg L, et al. Behav Genet, 2008 Jan. PMID 18066658, Free PMC Article
    5. Sequencing of canine 5-hydroxytriptamine receptor (5-HTR) 1B, 2A, 2C genes and identification of polymorphisms in the 5-HTR1B gene. Masuda K, et al. J Vet Med Sci, 2004 Aug. PMID 15353848

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gene does not play a major role in the variation in aggression in the Golden Retrievers.
      Title: Evaluation of the serotonergic genes htr1A, htr1B, htr2A, and slc6A4 in aggressive behavior of golden retriever dogs.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled serotonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in bone remodeling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of behavior IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    5-hydroxytryptamine receptor 1B
    Names
    5-HT-1B
    5-HT1B
    5-HT1D beta
    5-HT1D subtype beta
    5-HTR1B
    5-Hydroxytryptamine 1D receptor subtype beta
    serotonin receptor 1B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006948.1 → NP_001006949.1  5-hydroxytryptamine receptor 1B

      See identical proteins and their annotated locations for NP_001006949.1

      Status: PROVISIONAL

      Source sequence(s)
      AB193090
      UniProtKB/Swiss-Prot
      P79250, Q6VVV0
      UniProtKB/TrEMBL
      A0A8C0KGB7
      Related
      ENSCAFP00845011816.1, ENSCAFT00845015216.1
      Conserved Domains (1) summary
      cd15333
      Location:45 → 379
      7tmA_5-HT1B_1D; serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051816.1 Reference ROS_Cfam_1.0

      Range
      39430205..39431374 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049272.1 Alternate UMICH_Zoey_3.1

      Range
      38755029..38756198 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

      Range
      38739892..38741061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

      Range
      38869413..38870583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      38541798..38542967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P79250.2 GenPept UniProtKB/Swiss-Prot:P79250

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.