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    HRAS HRas proto-oncogene, GTPase [ Canis lupus familiaris (dog) ]

    Gene ID: 403735, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HRASprovided by VGNC
    Official Full Name
    HRas proto-oncogene, GTPaseprovided by VGNC
    Primary source
    VGNC:VGNC:56090
    See related
    Ensembl:ENSCAFG00845029661
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    H-RAS
    Orthologs
    human mouse all
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    Genomic context

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    See HRAS in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (26227144..26230043, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (25291831..25293704, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (25994065..25995938, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (25736932..25738805, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (25381917..25383790, complement)

    Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene phosphatidylserine synthase 2 Neighboring gene ribonuclease/angiogenin inhibitor 1 Neighboring gene uncharacterized LOC111090924 Neighboring gene USP6 N-terminal-like protein Neighboring gene leucine rich repeat containing 56 Neighboring gene lamin tail domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ultra-frequent HRAS p.Q61R somatic mutation in canine acanthomatous ameloblastoma reveals pathogenic similarities with human ameloblastoma. Peralta S, et al. Vet Comp Oncol, 2019 Sep. PMID 31041834
    2. Ras protein contributes to cerebral vasospasm in a canine double-hemorrhage model. Yamaguchi M, et al. Stroke, 2004 Jul. PMID 15143294
    3. Proteomics profiling of Madin-Darby canine kidney plasma membranes reveals Wnt-5a involvement during oncogenic H-Ras/TGF-beta-mediated epithelial-mesenchymal transition. Chen YS, et al. Mol Cell Proteomics, 2011 Feb. PMID 20511395, Free PMC Article
    4. Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains. Song KS, et al. J Biol Chem, 1996 Apr 19. PMID 8621645
    5. High sequence similarity within ras exons 1 and 2 in different mammalian species and phylogenetic divergence of the ras gene family. Watzinger F, et al. Mamm Genome, 1998 Mar. PMID 9501305

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study demonstrated that RNA sequencing, Sanger sequencing and restriction fragment length polymorphism assays to demonstrate that 94% of canine acanthomatous ameloblastoma harbor a somatic HRAS p.Q61R mutation.
      Title: Ultra-frequent HRAS p.Q61R somatic mutation in canine acanthomatous ameloblastoma reveals pathogenic similarities with human ameloblastoma.
    2. Wnt-5a is involved during oncogenic H-Ras/TGF-beta-mediated epithelial-mesenchymal transition
      Title: Proteomics profiling of Madin-Darby canine kidney plasma membranes reveals Wnt-5a involvement during oncogenic H-Ras/TGF-beta-mediated epithelial-mesenchymal transition.
    3. Ras contributes to cerebral vasospasm, and inhibitors of Ras FTase may have potential in the management of cerebral vasospasm.
      Title: Ras protein contributes to cerebral vasospasm in a canine double-hemorrhage model.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GDP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular senescence IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GTPase HRas
    Names
    ras p21
    v-Ha-ras Harvey rat sarcoma viral oncogene homolog
    NP_001273998.1
    NP_001273999.1
    XP_038279296.1
    XP_038279297.1
    XP_038279298.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287069.1 → NP_001273998.1  GTPase HRas isoform 1

      See identical proteins and their annotated locations for NP_001273998.1

      Status: INFERRED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAAUVH010000176
      UniProtKB/TrEMBL
      A0A8C0K1I4, A0A8C0MQL3, A0A8C0TJS5, A0A8I3Q1I3, A0A8P0NRX0
      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    2. NM_001287070.1 → NP_001273999.1  GTPase HRas isoform 2

      See identical proteins and their annotated locations for NP_001273999.1

      Status: INFERRED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      JAAUVH010000176
      UniProtKB/TrEMBL
      A0A8C0K3Y8, A0A8C0MQJ2, A0A8I3Q3V9
      Related
      ENSCAFP00845041226.1, ENSCAFT00845052537.1
      Conserved Domains (1) summary
      cd04138
      Location:3 → 150
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051822.1 Reference ROS_Cfam_1.0

      Range
      26227144..26230043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038423368.1 → XP_038279296.1  GTPase HRas isoform X1

      UniProtKB/TrEMBL
      A0A8C0K1I4, A0A8C0MQL3, A0A8C0TJS5, A0A8I3Q1I3, A0A8P0NRX0
      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    2. XM_038423370.1 → XP_038279298.1  GTPase HRas isoform X2

      UniProtKB/TrEMBL
      A0A8C0K3Y8, A0A8C0MQJ2, A0A8I3Q3V9
      Conserved Domains (1) summary
      cd04138
      Location:3 → 150
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    3. XM_038423369.1 → XP_038279297.1  GTPase HRas isoform X1

      UniProtKB/TrEMBL
      A0A8C0K1I4, A0A8C0MQL3, A0A8C0TJS5, A0A8I3Q1I3, A0A8P0NRX0
      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049278.1 Alternate UMICH_Zoey_3.1

      Range
      25736932..25738805 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

      Range
      25381917..25383790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

      Range
      25994065..25995938 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      25291831..25293704 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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