KCNJ2 potassium inwardly rectifying channel subfamily J member 2 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: KCNJ2provided by VGNC
Official Full Name: potassium inwardly rectifying channel subfamily J member 2provided by VGNC
Primary source: VGNC:VGNC:42263
See related: Ensembl:ENSCAFG00845005439
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	9	NC_051813.1 (18122955..18129749)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	9	NC_006591.4 (17360013..17366796)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	9	NC_049230.1 (10426806..10433589, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	9	NC_049269.1 (17067115..17073888)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	9	NC_049750.1 (10461025..10467799, complement)

Chromosome 9 - NC_051813.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regional differences in Kir2 expression likely underlie regional distinctions in inward rectifier potassium current characteristics.
Title: Regional variation of the inwardly rectifying potassium current in the canine heart and the contributions to differences in action potential repolarization.
Congestive heart failure upregulates fibroblast KCNJ2 expression and currents, hyperpolarizing RMP, increasing Ca(2+) entry, and enhancing atrial fibroblast proliferation. Remodeling-induced fibroblast KCNJ2 may play a role in atrial fibrillation.
Title: Fibroblast inward-rectifier potassium current upregulation in profibrillatory atrial remodeling.
The expression of inward rectifier potassium channels mRNA was increased after subarachnoid hemorrhage.
Title: Expression and function of inwardly rectifying potassium channels after experimental subarachnoid hemorrhage.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables inward rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in potassium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: inward rectifier potassium channel 2

Names: IRK-1; cardiac inward rectifier KIR2.1; cardiac inward rectifier potassium channel; inward rectifier K(+) channel Kir2.1; inwardly rectifying potassium channel Kir2.1; potassium channel, inwardly rectifying subfamily J member 2; potassium voltage-gated channel subfamily J member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003120.4 → NP_001003120.1 inward rectifier potassium channel 2

See identical proteins and their annotated locations for NP_001003120.1

Status: VALIDATED

Source sequence(s)

JAAUVH010000313

UniProtKB/Swiss-Prot

Q9MYY9

UniProtKB/TrEMBL

A0A8C0R4J6, H8F4N3

Related

ENSCAFP00845007576.1, ENSCAFT00845009690.1

Conserved Domains (3) summary

pfam01007
Location:48 → 186

IRK; Inward rectifier potassium channel

pfam08466
Location:1 → 47

IRK_N; Inward rectifier potassium channel N-terminal

pfam17655
Location:193 → 366

IRK_C; Inward rectifier potassium channel C-terminal domain