LEP leptin [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: LEPprovided by VGNC
Official Full Name: leptinprovided by VGNC
Primary source: VGNC:VGNC:42637
See related: Ensembl:ENSCAFG00845025165
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: OB
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	14	NC_051818.1 (7880580..7897895, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	14	NC_006596.4 (7802696..7807108, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	14	NC_049235.1 (7975126..7979538, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	14	NC_049274.1 (8087574..8091986, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	14	NC_049755.1 (7828397..7832809, complement)

Chromosome 14 - NC_051818.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This is the first report regarding the pattern of leptin during whole pregnancy and lactation. The present work lays the groundwork for further studies on endocrine homeostatic mechanisms using the dog as a model for human medicine
Title: Serum concentration dynamic of energy homeostasis hormones, leptin, insulin, thyroid hormones, and cortisol throughout canine pregnancy and lactation.
Leptin and insulin-like growth factor 1 may support spermatogenesis in adult dogs and mediate Leydig cell function
Title: Different expression of leptin and IGF1 in the adult and prepubertal testis in dogs.
This study evaluated the differences in leptin, adiponectin, and serotonin between lean and obese dogs.
Title: Leptin, adiponectin and serotonin levels in lean and obese dogs.
These results indicate that both leptin and leptin receptor mRNA are present in the canine corpus luteum during the non-pregnant luteal phase and pregnancy.
Title: Leptin and leptin receptor gene expression in the canine corpus luteum during diestrus, pregnancy and after aglepristone-induced luteolysis.
fasting plasma leptin concentration was directly negatively associated with fasting insulin sensitivity and positively associated with beta-cell function
Title: Compensation for obesity-induced insulin resistance in dogs: assessment of the effects of leptin, adiponectin, and glucagon-like peptide-1 using path analysis.
high-fat feeding induces resistance to the coronary vascular effects of leptin, and this represents an early protective adaptation against endothelial dysfunction
Title: Leptin resistance extends to the coronary vasculature in prediabetic dogs and provides a protective adaptation against endothelial dysfunction.
plasma leptin concentration analysis in dogs
Title: Plasma leptin concentration in dogs: effects of body condition score, age, gender and breeds.
Leptin dilates canine small mesenteric arteries and veins by a mechanism involving endothelial release of nitric oxide.
Title: Vasodilator effects of leptin on canine isolated mesenteric arteries and veins.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info	PubMed
enables peptide hormone receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of protein kinase C activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in energy reserve metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of appetite by leptin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of TOR signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of p38MAPK cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to insulin	IEA Inferred from Electronic Annotation more info	PubMed
involved_in tyrosine phosphorylation of STAT protein	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: leptin

Names: leptin (obesity homolog, mouse); obesity factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.