TNNI3 troponin I3, cardiac type [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: TNNI3provided by VGNC
Official Full Name: troponin I3, cardiac typeprovided by VGNC
Primary source: VGNC:VGNC:47689
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	1	NC_051805.1 (103128720..103131893)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	1	NC_006583.4 (102532199..102535372)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	1	NC_049222.1 (103241266..103244439)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	1	NC_049261.1 (102765644..102768817)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	1	NC_049742.1 (102477237..102480410)

Chromosome 1 - NC_051805.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

No statistical differences were found between CRP and cTnI levels, either before or after surgical correction of brachycephaly in dogs.
Title: Clinical assessment and C-reactive protein (CRP), haptoglobin (Hp), and cardiac troponin I (cTnI) values of brachycephalic dogs with upper airway obstruction before and after surgery.
The objective of this study was to evaluate the correlation between anatomical components, clinical signs and several biomarkers, used to determine systemic inflammation and myocardial damage in dogs with brachycephalic upper airway obstructive syndrome.
Title: Evaluation of C-reactive protein, haptoglobin and cardiac troponin 1 levels in brachycephalic dogs with upper airway obstructive syndrome.
The use of NT-pro-BNP and troponin I levels as prognostic indicators for canine heart failure is reported.
Title: NT-pro-BNP and troponin I as predictors of mortality in dogs with heart failure.
[NT-proBNP] concentration is significantly higher in dogs with pre-capillary pulmonary hypertension (PH) when compared to dogs with respiratory disease without PH; [NT-proANP] and [cTnI] were not elevated in dogs with pre-capillary PH.
Title: NT-proBNP, NT-proANP and cTnI concentrations in dogs with pre-capillary pulmonary hypertension.
Moderate exercise does not present a confounding variable in the interpretation of cardiac tropinin I and C-reactive protein concentrations in normal dogs.
Title: The influence of high-intensity moderate duration exercise on cardiac troponin I and C-reactive protein in sled dogs.
Analysis of troponin I concentration has potential to increase knowledge of overall cardiac remodeling in dogs with mitral valve disease; the effect of age on troponin I levels should be considered in these patients.
Title: Cardiac troponin I is associated with severity of myxomatous mitral valve disease, age, and C-reactive protein in dogs.
Serum troponin I is high in dogs with either precapillary and postcapillary pulmonary hypertension (PH); myocardial damage in dogs with postcapillary PH is likely the consequence of increased mitral valve disease severity.
Title: Serum cardiac troponin I concentration in dogs with precapillary and postcapillary pulmonary hypertension.
The incidence of myocardial injury due to ehrlichiosis, as demonstrated by elevated cardiac troponin I blood levels, is reported.
Title: Serum cardiac troponin I concentration in dogs with ehrlichiosis.
Circulating cTnI and pro-matrix metallopeptidase 9 increase in proportion to the severity of acute pulmonary thromboembolism
Title: Severity dependent increases in circulating cardiac troponin I and MMP-9 concentrations after experimental acute pulmonary thromboembolism.

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General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in muscle contraction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of troponin complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: troponin I, cardiac muscle

Names: cardiac troponin I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003041.1 → NP_001003041.1 troponin I, cardiac muscle

See identical proteins and their annotated locations for NP_001003041.1

Status: PROVISIONAL

Source sequence(s)

AF506750

UniProtKB/Swiss-Prot

Q8MKD5

UniProtKB/TrEMBL

A0A8C0KWK5

Conserved Domains (2) summary

pfam11636
Location:1 → 32

Troponin-I_N; Troponin I residues 1-32

pfam00992
Location:47 → 178

Troponin