U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    G6PC1 glucose-6-phosphatase catalytic subunit 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 403492, updated on 10-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    G6PC1provided by VGNC
    Official Full Name
    glucose-6-phosphatase catalytic subunit 1provided by VGNC
    Primary source
    VGNC:VGNC:41040
    See related
    Ensembl:ENSCAFG00845006712
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    G6PC; G6Pase
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See G6PC1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (20851596..20862184, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (19594513..19605089, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (20005407..20015994, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (19636449..19647026, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (19902743..19913338, complement)

    Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene RUN domain containing 1 Neighboring gene prostaglandin E synthase 3 like Neighboring gene alanyl-tRNA editing protein Aarsd1 Neighboring gene uncharacterized LOC102154826 Neighboring gene amine oxidase copper containing 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Selective stimulation of G-6-Pase catalytic subunit but not G-6-P transporter gene expression by glucagon in vivo and cAMP in situ. Hornbuckle LA, et al. Am J Physiol Endocrinol Metab, 2004 May. PMID 14722027
    2. Isolation and nucleotide sequence of canine glucose-6-phosphatase mRNA: identification of mutation in puppies with glycogen storage disease type Ia. Kishnani PS, et al. Biochem Mol Med, 1997 Aug. PMID 9259982
    3. Selective tonic inhibition of G-6-Pase catalytic subunit, but not G-6-P transporter, gene expression by insulin in vivo. Hornbuckle LA, et al. Am J Physiol Endocrinol Metab, 2001 Oct. PMID 11551847
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables glucose-6-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glucose 6-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    glucose-6-phosphatase catalytic subunit 1; glucose-6-phosphatase
    Names
    glucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gierke disease)
    XP_038341382.1
    XP_038403145.1
    XP_038467111.1
    XP_038485984.1
    XP_038532300.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419280.1 → NP_001406209.1  glucose-6-phosphatase catalytic subunit 1

      Status: VALIDATED

      Source sequence(s)
      JAAUVH010000313
      UniProtKB/TrEMBL
      A0A8C0M1R7, A0A8C0R019, A0A8I3MZQ1

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051813.1 Reference ROS_Cfam_1.0

      Range
      20851596..20862184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038676372.1 → XP_038532300.1  glucose-6-phosphatase

      Related
      ENSCAFP00845009292.1, ENSCAFT00845011909.1
      Conserved Domains (1) summary
      cd03381
      Location:42 → 280
      PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049269.1 Alternate UMICH_Zoey_3.1

      Range
      19636449..19647026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038485454.1 → XP_038341382.1  glucose-6-phosphatase

      Conserved Domains (1) summary
      cd03381
      Location:42 → 280
      PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

      Range
      19902743..19913338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038611183.1 → XP_038467111.1  glucose-6-phosphatase

      Conserved Domains (1) summary
      cd03381
      Location:42 → 280
      PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

      Range
      20005407..20015994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038547217.1 → XP_038403145.1  glucose-6-phosphatase

      UniProtKB/Swiss-Prot
      O19133
      UniProtKB/TrEMBL
      A0A8C0M1R7, A0A8C0R019, A0A8I3MZQ1
      Conserved Domains (1) summary
      cd03381
      Location:42 → 280
      PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      19594513..19605089 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038630056.1 → XP_038485984.1  glucose-6-phosphatase

      Conserved Domains (1) summary
      cd03381
      Location:42 → 280
      PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001002993.2: Suppressed sequence

      Description
      NM_001002993.2: This RefSeq was removed because there were several differences (mismatches and/or insertions and/or deletions) compared to available sequence data.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O19133.1 GenPept UniProtKB/Swiss-Prot:O19133

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials