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    PPP3CA protein phosphatase 3 catalytic subunit alpha [ Canis lupus familiaris (dog) ]

    Gene ID: 403486, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PPP3CAprovided by VGNC
    Official Full Name
    protein phosphatase 3 catalytic subunit alphaprovided by VGNC
    Primary source
    VGNC:VGNC:44918
    See related
    Ensembl:ENSCAFG00845024635
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See PPP3CA in Genome Data Viewer
    Location:
    chromosome: 32
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 32 NC_051836.1 (22910701..23219264, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 32 NC_006614.4 (18960549..19234052)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 32 NC_049253.1 (16885817..17195548)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 32 NC_049292.1 (22888729..23197885, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 32 NC_049773.1 (22670376..22979752, complement)

    Chromosome 32 - NC_051836.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102153771 Neighboring gene uncharacterized LOC119867159 Neighboring gene uncharacterized LOC106558128 Neighboring gene glutathione S-transferase P-like Neighboring gene uncharacterized LOC119867193 Neighboring gene uncharacterized LOC119867160 Neighboring gene uncharacterized LOC102153933

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcineurin-NFAT signaling cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of calcineurin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein phosphatase 3 catalytic subunit alpha; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
    Names
    calcineurin catalytic subunit
    NP_001184025.1
    XP_038299701.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001197096.1 → NP_001184025.1  protein phosphatase 3 catalytic subunit alpha

      See identical proteins and their annotated locations for NP_001184025.1

      Status: VALIDATED

      Source sequence(s)
      AAEX03016788
      UniProtKB/TrEMBL
      A0A8C0P395, A0A8I3PMK3
      Related
      ENSCAFP00845034170.1, ENSCAFT00845043614.1
      Conserved Domains (1) summary
      cd07416
      Location:41 → 345
      MPP_PP2B; PP2B, metallophosphatase domain

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051836.1 Reference ROS_Cfam_1.0

      Range
      22910701..23219264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038443773.1 → XP_038299701.1  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1

      UniProtKB/TrEMBL
      A0A8I3PS73
      Conserved Domains (1) summary
      cd07416
      Location:41 → 347
      MPP_PP2B; PP2B, metallophosphatase domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049292.1 Alternate UMICH_Zoey_3.1

      Range
      22888729..23197885 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049773.1 Alternate UNSW_CanFamBas_1.0

      Range
      22670376..22979752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049253.1 Alternate UU_Cfam_GSD_1.0

      Range
      16885817..17195548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006614.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      18960549..19234052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials