HEY1 hes related family bHLH transcription factor with YRPW motif 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: HEY1provided by VGNC
Official Full Name: hes related family bHLH transcription factor with YRPW motif 1provided by VGNC
Primary source: VGNC:VGNC:54114
See related: Ensembl:ENSCAFG00845029695
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: HERP1; HESR1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 29

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	29	NC_051833.1 (27308721..27311675, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	29	NC_006611.4 (27458786..27461729, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	29	NC_049250.1 (27749711..27752657, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	29	NC_049289.1 (27354259..27357186, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	29	NC_049770.1 (27393148..27396070, complement)

Chromosome 29 - NC_051833.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in anterior/posterior pattern specification	IEA Inferred from Electronic Annotation more info	PubMed
involved_in circulatory system development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of neurogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: hairy/enhancer-of-split related with YRPW motif protein 1

Names: HESR-1; bHLH protein Hesr-1/Hey1; hairy and enhancer of split-related protein 1; hairy/enhancer-of-split related with YRPW motif 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002953.1 → NP_001002953.1 hairy/enhancer-of-split related with YRPW motif protein 1

See identical proteins and their annotated locations for NP_001002953.1

Status: PROVISIONAL

Source sequence(s)

AJ388551

UniProtKB/Swiss-Prot

Q9TSZ2

UniProtKB/TrEMBL

A0A8C0L2N7, A0A8C0Z1N3

Related

ENSCAFP00845041270.1, ENSCAFT00845052586.1

Conserved Domains (2) summary

smart00511
Location:120 → 166

ORANGE; Orange domain

cd00083
Location:50 → 107

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...