U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    lman2la lectin, mannose-binding 2-like a [ Danio rerio (zebrafish) ]

    Gene ID: 403038, updated on 12-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    lman2laprovided by ZNC
    Official Full Name
    lectin, mannose-binding 2-like aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040715-4
    See related
    AllianceGenome:ZFIN:ZDB-GENE-040715-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    lman2l; VIP36-like; zgc:113949
    Summary
    Acts upstream of or within mechanosensory lateral line system development. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in neuromast and neuromast support cell. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human LMAN2L (lectin, mannose binding 2 like). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See lman2la in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (72377823..72383840)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (71593317..71599334)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene T-box transcription factor 3a Neighboring gene mitochondrial fission process 1 Neighboring gene WW domain binding protein 1 Neighboring gene thioredoxin domain-containing protein 2-like Neighboring gene PH and SEC7 domain-containing protein 4

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The vesicular integral protein-like gene is essential for development of a mechanosensory system in zebrafish. Chong M, et al. Dev Neurobiol, 2008 Oct. PMID 18712783
    2. Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development. Golling G, et al. Nat Genet, 2002 Jun. PMID 12006978
    3. Functional characterization of zebrafish orthologs of the human Beta 3-Glucosyltransferase B3GLCT gene mutated in Peters Plus Syndrome. Weh E, et al. PLoS One, 2017. PMID 28926587, Free PMC Article
    4. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within mechanosensory lateral line system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    lectin, mannose-binding 2-like a
    Names
    vesicular integral-membrane protein VIP36-like protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205725.2 → NP_991288.2  lectin, mannose-binding 2-like a precursor

      See identical proteins and their annotated locations for NP_991288.2

      Status: PROVISIONAL

      Source sequence(s)
      BC097031
      UniProtKB/TrEMBL
      Q4QRF6
      Conserved Domains (1) summary
      cl14058
      Location:27 → 283
      lectin_L-type; legume lectins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      72377823..72383840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials