RAB19 RAB19, member RAS oncogene family [Homo sapiens (human)] - Gene

Summary

Official Symbol: RAB19provided by HGNC
Official Full Name: RAB19, member RAS oncogene familyprovided by HGNC
Primary source: HGNC:HGNC:19982
See related: Ensembl:ENSG00000146955 AllianceGenome:HGNC:19982
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RAB19B
Summary: Predicted to enable GTPase activity. Predicted to be involved in autophagosome assembly and intracellular protein transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in colon (RPKM 1.1), thyroid (RPKM 1.0) and 15 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (140404058..140427974)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (141718006..141742144)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (140103858..140127774)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WDR38, a novel equatorial segment protein, interacts with the GTPase protein RAB19 and Golgi protein GM130 to play roles in acrosome biogenesis.
Title: WDR38, a novel equatorial segment protein, interacts with the GTPase protein RAB19 and Golgi protein GM130 to play roles in acrosome biogenesis.
N6-methyladenosine (m6A)-mediated up-regulation of long noncoding RNA LINC01320 promotes the proliferation, migration, and invasion of gastric cancer via miR495-5p/RAB19 axis.
Title: N6-methyladenosine (m6A)-mediated up-regulation of long noncoding RNA LINC01320 promotes the proliferation, migration, and invasion of gastric cancer via miR495-5p/RAB19 axis.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular exosome	HDA more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ras-related protein Rab-19

Names: GTP-binding protein RAB19B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008749.3 → NP_001008749.2 ras-related protein Rab-19

See identical proteins and their annotated locations for NP_001008749.2

Status: VALIDATED

Source sequence(s)

AC069335, BC140796, DN996121, DY655778

Consensus CDS

CCDS34762.2

UniProtKB/Swiss-Prot

A4D1S5, A4D1S6, B2RTS6, B5MDR2, Q9UL27

Related

ENSP00000440167.1, ENST00000537763.6

Conserved Domains (1) summary

cd01864
Location:15 → 179

Rab19; Rab GTPase family 19 (Rab19)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

140404058..140427974

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005249997.4 → XP_005250054.1 ras-related protein Rab-19 isoform X2

Conserved Domains (2) summary

cd01864
Location:15 → 167

Rab19; Rab GTPase family 19 (Rab19)

smart00175
Location:18 → 170

RAB; Rab subfamily of small GTPases
XM_005249998.4 → XP_005250055.1 ras-related protein Rab-19 isoform X3

Conserved Domains (2) summary

smart00175
Location:18 → 168

RAB; Rab subfamily of small GTPases

cl21455
Location:15 → 165

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_005249996.4 → XP_005250053.1 ras-related protein Rab-19 isoform X1

See identical proteins and their annotated locations for XP_005250053.1

UniProtKB/Swiss-Prot

A4D1S5, A4D1S6, B2RTS6, B5MDR2, Q9UL27

Related

ENSP00000348778.3, ENST00000356407.3

Conserved Domains (1) summary

cd01864
Location:15 → 179

Rab19; Rab GTPase family 19 (Rab19)
XM_047420375.1 → XP_047276331.1 ras-related protein Rab-19 isoform X2
XM_017012207.2 → XP_016867696.1 ras-related protein Rab-19 isoform X1

UniProtKB/Swiss-Prot

A4D1S5, A4D1S6, B2RTS6, B5MDR2, Q9UL27

Conserved Domains (1) summary

cd01864
Location:15 → 179

Rab19; Rab GTPase family 19 (Rab19)