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    LINC00336 long intergenic non-protein coding RNA 336 [ Homo sapiens (human) ]

    Gene ID: 401253, updated on 17-Aug-2024

    Summary

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    Official Symbol
    LINC00336provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 336provided by HGNC
    Primary source
    HGNC:HGNC:33813
    See related
    Ensembl:ENSG00000197251 AllianceGenome:HGNC:33813
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C6orf227; NCRNA00336
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See LINC00336 in Genome Data Viewer
    Location:
    6p21.31
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (33586104..33593338, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (33407294..33414528, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (33553881..33561115, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91452 Neighboring gene RNA, 7SL, cytoplasmic 26, pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91454 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24361 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33546627-33547272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33552868-33553862 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:33557672-33558871 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33559025-33559664 Neighboring gene BCL2 antagonist/killer 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33560945-33561584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24366 Neighboring gene gametogenetin binding protein 1 (pseudogene) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33566996-33567496 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33567497-33567997 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33571503-33572004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33572005-33572504 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:33574668-33575174 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33575775-33576317 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33577246-33577832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33577833-33578418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17047 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17049 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17048 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:33589316-33589501 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33590023-33590572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33590573-33591121 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17051 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33597027-33597903 Neighboring gene uncharacterized LOC124901305 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33602349-33602895 Neighboring gene inositol 1,4,5-trisphosphate receptor type 3 Neighboring gene ITPR3 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33618418-33618918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33618919-33619419 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33624122-33624658 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33625731-33626265 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33626906-33627416 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33636045-33636676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33636677-33637307 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33641013-33641534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33658493-33659470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33659471-33660446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33660447-33661424 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:33662237-33663436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33665333-33666308 Neighboring gene microRNA 3934 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA. Wang M, et al. Cell Death Differ, 2019 Nov. PMID 30787392, Free PMC Article
    2. Heterogeneous ozone effects on the DNA methylome of bronchial cells observed in a crossover study. Bind MC, et al. Sci Rep, 2020 Sep 25. PMID 32978449, Free PMC Article
    3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. Barcellos LF, et al. PLoS Genet, 2009 Oct. PMID 19851445, Free PMC Article
    4. Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy. Jin S, et al. Nat Commun, 2022 Sep 3. PMID 36057605, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Heterogeneous ozone effects on the DNA methylome of bronchial cells observed in a crossover study.
      Title: Heterogeneous ozone effects on the DNA methylome of bronchial cells observed in a crossover study.
    2. Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA.
      Title: Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Clone Names

    • FLJ43752

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_027908.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      Z93017
      Related
      ENST00000477984.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      33586104..33593338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      33407294..33414528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_207497.1: Suppressed sequence

      Description
      NM_207497.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZUF6.1 GenPept UniProtKB/Swiss-Prot:Q6ZUF6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.