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    PAIP2B poly(A) binding protein interacting protein 2B [ Homo sapiens (human) ]

    Gene ID: 400961, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PAIP2Bprovided by HGNC
    Official Full Name
    poly(A) binding protein interacting protein 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:29200
    See related
    Ensembl:ENSG00000124374 MIM:611018; AllianceGenome:HGNC:29200
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in brain (RPKM 9.7), thyroid (RPKM 9.0) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PAIP2B in Genome Data Viewer
    Location:
    2p13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (71182738..71227103, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (71193792..71238156, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (71409868..71454233, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:71345289-71345789 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:71356582-71357440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16015 Neighboring gene M-phase phosphoprotein 10 Neighboring gene methylmalonyl-CoA epimerase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16016 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:71384714-71384875 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:71388687-71389348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71411093-71411594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71411595-71412094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71453663-71454163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16017 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:71477764-71478264 Neighboring gene uncharacterized LOC105374797 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16018 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:71558505-71559192 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:71559193-71559878 Neighboring gene Sharpr-MPRA regulatory region 7735 Neighboring gene zinc finger protein 638 Neighboring gene RNA, U6 small nuclear 105, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study. Tang H, et al. Int J Cancer, 2017 Aug 15. PMID 28470677, Free PMC Article
    2. Regulation of poly(A)-binding protein through PABP-interacting proteins. Derry MC, et al. Cold Spring Harb Symp Quant Biol, 2006. PMID 17381337
    3. Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B. Berlanga JJ, et al. RNA, 2006 Aug. PMID 16804161, Free PMC Article
    4. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. Hirosawa M, et al. DNA Res, 1999 Oct 29. PMID 10574461
    5. High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Youn JY, et al. Mol Cell, 2018 Feb 1. PMID 29395067

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1155

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables mRNA regulatory element binding translation repressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation repressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polyadenylate-binding protein-interacting protein 2B
    Names
    PABP-interacting protein 2B
    PAIP-2B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020459.1 → NP_065192.1  polyadenylate-binding protein-interacting protein 2B

      See identical proteins and their annotated locations for NP_065192.1

      Status: VALIDATED

      Source sequence(s)
      AB032981, AC007881, DA247526, DA346299
      Consensus CDS
      CCDS46322.1
      UniProtKB/Swiss-Prot
      Q9ULR5
      Related
      ENSP00000244221.8, ENST00000244221.9
      Conserved Domains (1) summary
      pfam07145
      Location:107 → 120
      PAM2; Ataxin-2 C-terminal region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      71182738..71227103 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264311.5 → XP_005264368.1  polyadenylate-binding protein-interacting protein 2B isoform X2

      See identical proteins and their annotated locations for XP_005264368.1

      UniProtKB/Swiss-Prot
      Q9ULR5
      Conserved Domains (1) summary
      pfam07145
      Location:107 → 120
      PAM2; Ataxin-2 C-terminal region

    2. XM_005264310.5 → XP_005264367.1  polyadenylate-binding protein-interacting protein 2B isoform X2

      See identical proteins and their annotated locations for XP_005264367.1

      UniProtKB/Swiss-Prot
      Q9ULR5
      Conserved Domains (1) summary
      pfam07145
      Location:107 → 120
      PAM2; Ataxin-2 C-terminal region

    3. XM_011532842.4 → XP_011531144.1  polyadenylate-binding protein-interacting protein 2B isoform X1

      See identical proteins and their annotated locations for XP_011531144.1

      Conserved Domains (1) summary
      pfam07145
      Location:127 → 141
      PAM2; Ataxin-2 C-terminal region

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      71193792..71238156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342026.1 → XP_054198001.1  polyadenylate-binding protein-interacting protein 2B isoform X2

      UniProtKB/Swiss-Prot
      Q9ULR5

    2. XM_054342025.1 → XP_054198000.1  polyadenylate-binding protein-interacting protein 2B isoform X1

    3. XM_054342027.1 → XP_054198002.1  polyadenylate-binding protein-interacting protein 2B isoform X2

      UniProtKB/Swiss-Prot
      Q9ULR5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULR5.2 GenPept UniProtKB/Swiss-Prot:Q9ULR5

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