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    MYPT-75D Myosin phosphatase targeting subunit 75D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40032, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MYPT-75Dprovided by FlyBase
    Official Full Name
    Myosin phosphatase targeting subunit 75Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036801
    Locus tag
    Dmel_CG6896
    See related
    AllianceGenome:FB:FBgn0036801
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6896; Dmel\CG6896; Mypt-75d; MYPT75-D; mypt75D; MYPT75D
    Summary
    Enables myosin phosphatase regulator activity and protein phosphatase 1 binding activity. Involved in imaginal disc-derived wing morphogenesis. Predicted to be active in plasma membrane. Is expressed in adult head. Orthologous to human PPP1R16A (protein phosphatase 1 regulatory subunit 16A) and PPP1R16B (protein phosphatase 1 regulatory subunit 16B). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See MYPT-75D in Genome Data Viewer
    Location:
    75D4-75D5; 3-45 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18625959..18667177)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18619059..18660277)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Proline-CGG 2-3 Neighboring gene non-stop Neighboring gene aurora borealis Neighboring gene uncharacterized protein Neighboring gene Caprin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An in vitro method for studying subcellular rearrangements during cell polarization in Drosophila melanogaster hemocytes. Edwards SS, et al. Mech Dev, 2018 Dec. PMID 30096416
    2. Myosin II Controls Junction Fluctuations to Guide Epithelial Tissue Ordering. Curran S, et al. Dev Cell, 2017 Nov 20. PMID 29107560, Free PMC Article
    3. Trpml controls actomyosin contractility and couples migration to phagocytosis in fly macrophages. Edwards-Jorquera SS, et al. J Cell Biol, 2020 Mar 2. PMID 31940424, Free PMC Article
    4. A self-organized biomechanical network drives shape changes during tissue morphogenesis. Munjal A, et al. Nature, 2015 Aug 20. PMID 26214737
    5. MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes. Venken KJ, et al. Nat Methods, 2011 Sep. PMID 21985007, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin phosphatase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein phosphatase 1 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myosin phosphatase targeting subunit 75D
    Names
    CG6896-PA
    CG6896-PB
    CG6896-PC
    CG6896-PD
    MYPT-75D-PA
    MYPT-75D-PB
    MYPT-75D-PC
    MYPT-75D-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18625959..18667177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275088.1 → NP_001262017.1  myosin phosphatase targeting subunit 75D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262017.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFV2
      Conserved Domains (4) summary
      cd00204
      Location:146 → 332
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:123 → 215
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:282 → 332
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:123 → 149
      ANK; ANK repeat [structural motif]

    2. NM_001275090.1 → NP_001262019.1  myosin phosphatase targeting subunit 75D, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SY34, Q9VVR3
      Conserved Domains (4) summary
      cd00204
      Location:146 → 332
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:123 → 215
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:282 → 332
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:123 → 149
      ANK; ANK repeat [structural motif]

    3. NM_140792.2 → NP_649049.1  myosin phosphatase targeting subunit 75D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649049.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SY34, Q9VVR3
      Related
      FBpp0074816
      Conserved Domains (4) summary
      cd00204
      Location:146 → 332
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:123 → 215
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:282 → 332
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:123 → 149
      ANK; ANK repeat [structural motif]

    4. NM_001275089.2 → NP_001262018.1  myosin phosphatase targeting subunit 75D, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262018.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SY34, Q9VVR3
      Conserved Domains (4) summary
      cd00204
      Location:146 → 332
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:123 → 215
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:282 → 332
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:123 → 149
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFV2 M9PFV2
    Q8SY34 Q8SY34

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