ctnna1.S catenin alpha 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ctnna1.S
Official Full Name: catenin alpha 1 S homeolog
Primary source: Xenbase:XB-GENE-865285
Locus tag: XELAEV_18020018mg
See related: EnsemblRapid:ENSXLAG00005019080 AllianceGenome:Xenbase:XB-GENE-865285
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: cap102; catna1; ctnna1
Summary: Predicted to enable several functions, including actin filament binding activity; beta-catenin binding activity; and cadherin binding activity. Predicted to act upstream of or within cell migration and cell-cell adhesion. Predicted to be located in several cellular components, including actin cytoskeleton; adherens junction; and nucleus. Predicted to be part of catenin complex. Human ortholog(s) of this gene implicated in patterned macular dystrophy 2. Orthologous to human CTNNA1 (catenin alpha 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 3S

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3S	NC_054376.1 (14272487..14315393)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3S	NC_030729.1 (14059862..14103039)

Chromosome 3S - NC_054376.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest that the interactions of beta-catenin with alpha-catenin and GSK-3beta exert opposing effects on the terminal projections of ventral optic axons.
Title: GSK-3beta and alpha-catenin binding regions of beta-catenin exert opposing effects on the terminal ventral optic axonal projection.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info
enables cadherin binding	IEA Inferred from Electronic Annotation more info
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell-cell adhesion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
part_of catenin complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: catenin alpha 1 S homeolog

Names: alpha(E)-catenin; catenin (cadherin-associated protein), alpha 1, 102kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.