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    DLST dihydrolipoamide S-succinyltransferase [ Sus scrofa (pig) ]

    Gene ID: 397690, updated on 17-Aug-2024

    Summary

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    Official Symbol
    DLSTprovided by VGNC
    Official Full Name
    dihydrolipoamide S-succinyltransferaseprovided by VGNC
    Primary source
    VGNC:VGNC:87338
    See related
    Ensembl:ENSSSCG00000002374
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    DLST-tv1
    Expression
    Ubiquitous expression in heart (RPKM 105.0), psoas major muscle (RPKM 63.8) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See DLST in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 7 NC_010449.5 (98091161..98111267)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 7 NC_010449.4 (103935074..103955180)

    Chromosome 7 - NC_010449.5Genomic Context describing neighboring genes Neighboring gene YLP motif containing 1 Neighboring gene prospero homeobox 2 Neighboring gene ribosomal protein S6 kinase like 1 Neighboring gene placental growth factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Cloning, overexpression and mutagenesis of cDNA encoding dihydrolipoamide succinyltransferase component of the porcine 2-oxoglutarate dehydrogenase complex. Koike K, et al. Eur J Biochem, 2000 May. PMID 10806400
    2. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MYOD induced lnc-MEG3 promotes porcine satellite cell differentiation via interacting with DLST.
      Title: MYOD induced lnc-MEG3 promotes porcine satellite cell differentiation via interacting with DLST.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables dihydrolipoyllysine-residue succinyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of oxoglutarate dehydrogenase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
    Names
    2-oxoglutarate dehydrogenase complex component E2
    E2K
    E2o
    OGDC-E2
    PE2o
    dihydrolipamide succinyl transferase-like protein
    dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex
    NP_999562.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214397.1 → NP_999562.1  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor

      See identical proteins and their annotated locations for NP_999562.1

      Status: PROVISIONAL

      Source sequence(s)
      AB035206
      UniProtKB/Swiss-Prot
      Q9N0F1
      UniProtKB/TrEMBL
      A0A4X1TEJ1, A0A8D0UUD8
      Related
      ENSSSCP00000064766.1, ENSSSCT00000079698.1
      Conserved Domains (3) summary
      cd06849
      Location:72 → 144
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      TIGR01347
      Location:72 → 455
      sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)
      pfam00198
      Location:240 → 453
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010449.5 Reference Sscrofa11.1 Primary Assembly

      Range
      98091161..98111267
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N0F1.1 GenPept UniProtKB/Swiss-Prot:Q9N0F1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.