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    FSHR follicle stimulating hormone receptor [ Sus scrofa (pig) ]

    Gene ID: 397679, updated on 17-Aug-2024

    Summary

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    Official Symbol
    FSHRprovided by VGNC
    Official Full Name
    follicle stimulating hormone receptorprovided by VGNC
    Primary source
    VGNC:VGNC:102568
    See related
    Ensembl:ENSSSCG00000029084
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Restricted expression toward ovary (RPKM 4.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See FSHR in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 3 NC_010445.4 (91607236..91775255)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 3 NC_010445.3 (97500987..97591897)

    Chromosome 3 - NC_010445.4Genomic Context describing neighboring genes Neighboring gene neurexin 1 Neighboring gene protein mago nashi homolog Neighboring gene 60S ribosomal protein L26-like 1 pseudogene Neighboring gene microtubule-associated proteins 1A/1B light chain 3B pseudogene Neighboring gene malignant T-cell-amplified sequence 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Relationship between polymorphisms in exon 10 of FSHR gene and litter size in swine. Zhang XD, et al. Genet Mol Res, 2015 Jul 27. PMID 26345751
    2. Sequence and regulation of the porcine FSHR gene promoter. Wu W, et al. Anim Reprod Sci, 2015 Mar. PMID 25599592
    3. The expression of FSH receptor (FSHR) in the neonatal porcine ovary and its regulation by flutamide. Durlej M, et al. Reprod Domest Anim, 2011 Jun. PMID 20642491
    4. In vivo gene expression in granulosa cells during pig terminal follicular development. Bonnet A, et al. Reproduction, 2008 Aug. PMID 18456903
    5. The porcine follitropin receptor: cDNA cloning, functional expression and chromosomal localization of the gene. Remy JJ, et al. Gene, 1995 Oct 3. PMID 7590277

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-31 targets HSD17B14 and FSHR, and miR-20b targets HSD17B14 to affect apoptosis and steroid hormone metabolism of porcine ovarian granulosa cells.
      Title: MiR-31 targets HSD17B14 and FSHR, and miR-20b targets HSD17B14 to affect apoptosis and steroid hormone metabolism of porcine ovarian granulosa cells.
    2. This study showed that high levels of FSHR, AKT2, and APPL1 were expressed in the ovaries of high prolific breed pigs.
      Title: Expression of follicle-stimulating hormone receptor (FSHR), protein kinase B-2 (AKT2) and adapter protein with PH domain, PTB domain, and leucine zipper (APPL1) in pig ovaries.
    3. Activated TGF-beta signaling rescued miR-143-reduced FSHR and intracellular signaling molecules, and miR-143-induced porcine granulosa cell apoptosis.
      Title: TGF-β signaling controls FSHR signaling-reduced ovarian granulosa cell apoptosis through the SMAD4/miR-143 axis.
    4. The results showed that polymorphisms in exon 10 of the FSHR gene had a significant effect on litter size traits of Wannan Black and Berkshire pigs. These results can be applied for marker-assisted selection in the 2 swine breeds
      Title: Relationship between polymorphisms in exon 10 of FSHR gene and litter size in swine.
    5. These results showed that an increased FSHR gene expression level was accompanied with an increase in histone H3K9 acetylation levels, suggesting that histone H3K9 acetylation could regulate the expression of the porcine FSHR gene.
      Title: Sequence and regulation of the porcine FSHR gene promoter.
    6. This study tested whether prenatal and neonatal exposure to antiandrogen flutamide affected ovarian 17beta-estradiol synthesis and the associated gene expression in large antral follicles of adult pigs.
      Title: Elevated level of 17β-estradiol is associated with overexpression of FSHR, CYP19A1, and CTNNB1 genes in porcine ovarian follicles after prenatal and neonatal flutamide exposure.
    7. 248 F(2) animals from a Duroc and Meishan cross were genotyped for three FSHR SNPs at positions 74, 532 and 1166, and these were correlated with the phenotypes of litter size and corpus luteum number
      Title: Fine mapping the number of corpora lutea quantitative trait loci on SSC3: analysis of the porcine follicle-stimulating hormone receptor gene.
    8. findings suggest the FSH receptor may be involved in the early follicle formation in pigs, which begins during prenatal life.
      Title: The expression of FSH receptor (FSHR) in the neonatal porcine ovary and its regulation by flutamide.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables follicle-stimulating hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in follicle-stimulating hormone signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in male gonad development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    follicle-stimulating hormone receptor
    Names
    FSH-R
    follitropin receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214386.3 → NP_999551.2  follicle-stimulating hormone receptor precursor

      Status: VALIDATED

      Source sequence(s)
      AF025377, CR939120, HX237590
      UniProtKB/Swiss-Prot
      O77514, P49059
      UniProtKB/TrEMBL
      A0A8D0LK86, A0A8D1NAD5, A0A8D1R806, I3L9Z2
      Related
      ENSSSCP00000020856.2, ENSSSCT00000024756.2
      Conserved Domains (6) summary
      smart00013
      Location:20 → 50
      LRRNT; Leucine rich repeat N-terminal domain
      sd00033
      Location:51 → 71
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00001
      Location:379 → 626
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam12369
      Location:282 → 349
      GnHR_trans; Gonadotropin hormone receptor transmembrane region
      pfam13306
      Location:61 → 216
      LRR_5; Leucine rich repeats (6 copies)
      pfam13855
      Location:193 → 245
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010445.4 Reference Sscrofa11.1 Primary Assembly

      Range
      91607236..91775255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021085884.1 → XP_020941543.1  follicle-stimulating hormone receptor isoform X4

      UniProtKB/Swiss-Prot
      O77514, P49059
      UniProtKB/TrEMBL
      A0A8D0LK86, A0A8D1NAD5
      Conserved Domains (7) summary
      smart00013
      Location:20 → 50
      LRRNT; Leucine rich repeat N-terminal domain
      sd00033
      Location:51 → 71
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12369
      Location:224 → 287
      GnHR_trans; Gonadotropin hormone receptor transmembrane region
      pfam13855
      Location:72 → 130
      LRR_8; Leucine rich repeat
      cd14964
      Location:303 → 327
      7tm_GPCRs; TM helix 1 [structural motif]
      cl26222
      Location:61 → 216
      LRR_5; Leucine rich repeats (6 copies)
      cl28897
      Location:301 → 574
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_021085883.1 → XP_020941542.1  follicle-stimulating hormone receptor isoform X3

      UniProtKB/Swiss-Prot
      O77514, P49059
      UniProtKB/TrEMBL
      A0A8D0LK86, A0A8D1NAD5
      Conserved Domains (7) summary
      smart00013
      Location:20 → 50
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:99 → 122
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:51 → 71
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12369
      Location:232 → 299
      GnHR_trans; Gonadotropin hormone receptor transmembrane region
      pfam13855
      Location:143 → 195
      LRR_8; Leucine rich repeat
      cd14964
      Location:315 → 339
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:313 → 586
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_021085881.1 → XP_020941540.1  follicle-stimulating hormone receptor isoform X1

      UniProtKB/Swiss-Prot
      O77514, P49059
      UniProtKB/TrEMBL
      A0A8D0LK86, A0A8D1NAD5
      Conserved Domains (7) summary
      smart00013
      Location:20 → 50
      LRRNT; Leucine rich repeat N-terminal domain
      sd00033
      Location:51 → 71
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12369
      Location:281 → 348
      GnHR_trans; Gonadotropin hormone receptor transmembrane region
      pfam13855
      Location:192 → 244
      LRR_8; Leucine rich repeat
      cd14964
      Location:364 → 388
      7tm_GPCRs; TM helix 1 [structural motif]
      cl26222
      Location:61 → 215
      LRR_5; Leucine rich repeats (6 copies)
      cl28897
      Location:362 → 635
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. XM_021085882.1 → XP_020941541.1  follicle-stimulating hormone receptor isoform X2

      UniProtKB/Swiss-Prot
      O77514, P49059
      UniProtKB/TrEMBL
      A0A8D0LK86, A0A8D1NAD5
      Conserved Domains (7) summary
      smart00013
      Location:20 → 50
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:81 → 274
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:51 → 71
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12369
      Location:257 → 324
      GnHR_trans; Gonadotropin hormone receptor transmembrane region
      pfam13855
      Location:56 → 105
      LRR_8; Leucine rich repeat
      cd14964
      Location:340 → 364
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:338 → 611
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49059.2 GenPept UniProtKB/Swiss-Prot:P49059

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