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    RACK1 receptor for activated C kinase 1 [ Sus scrofa (pig) ]

    Gene ID: 397605, updated on 17-Aug-2024

    Summary

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    Official Symbol
    RACK1provided by VGNC
    Official Full Name
    receptor for activated C kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:100848
    See related
    Ensembl:ENSSSCG00000029724
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Ubiquitous expression in spleen (RPKM 804.7), ovary (RPKM 756.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See RACK1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 2 NC_010444.4 (57280192..57284846)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) Unplaced Scaffold NW_003538080.1 (58839..63692)

    Chromosome 2 - NC_010444.4Genomic Context describing neighboring genes Neighboring gene vomeronasal type-1 receptor 5 Neighboring gene tripartite motif containing 52 Neighboring gene uncharacterized LOC106508370 Neighboring gene tripartite motif containing 41 Neighboring gene transfer RNA valine (anticodon CAC)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Structure and genomic organization of porcine RACK1 gene. Chou YC, et al. Biochim Biophys Acta, 1999 Dec 23. PMID 10673032
    2. Porcine RACK1 negatively regulates the infection of classical swine fever virus and the NF-κB activation in PK-15 cells. Wang X, et al. Vet Microbiol, 2020 Jul. PMID 32605753
    3. Integrin β3, a RACK1 interacting protein, is critical for porcine reproductive and respiratory syndrome virus infection and NF-κB activation in Marc-145 cells. Yang C, et al. Virus Res, 2020 Jun. PMID 32247758
    4. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
    5. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Integrin beta3, a RACK1 interacting protein, is critical for porcine reproductive and respiratory syndrome virus infection and NF-kappaB activation in Marc-145 cells.
      Title: Integrin β3, a RACK1 interacting protein, is critical for porcine reproductive and respiratory syndrome virus infection and NF-κB activation in Marc-145 cells.
    2. Porcine RACK1 negatively regulates the infection of classical swine fever virus and the NF-kappaB activation in PK-15 cells.
      Title: Porcine RACK1 negatively regulates the infection of classical swine fever virus and the NF-κB activation in PK-15 cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein kinase C binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables translation regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in rescue of stalled ribosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    small ribosomal subunit protein RACK1
    Names
    G-beta like protein
    guanine nucleotide-binding protein subunit beta-2-like 1
    receptor of activated protein C kinase 1
    receptor of activated protein kinase C 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214332.1 → NP_999497.1  small ribosomal subunit protein RACK1

      See identical proteins and their annotated locations for NP_999497.1

      Status: PROVISIONAL

      Source sequence(s)
      Z33879
      UniProtKB/Swiss-Prot
      P63246
      UniProtKB/TrEMBL
      A0A4X1TXG2
      Related
      ENSSSCP00000023723.2, ENSSSCT00000022602.4
      Conserved Domains (2) summary
      cd00200
      Location:7 → 311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:18 → 61
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010444.4 Reference Sscrofa11.1 Primary Assembly

      Range
      57280192..57284846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63246.3 GenPept UniProtKB/Swiss-Prot:P63246

    Gene LinkOut

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